Glucose tolerance and cardiovascular mortality -: Comparison of fasting and 2-hour diagnostic criteria
Glucose tolerance and cardiovascular mortality -: Comparison of fasting and 2-hour diagnostic criteria
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DOI：
10.1001/archinte.161.3.397
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发表时间：
2001-02-12
影响因子：
--
通讯作者：
Qiao, Q
中科院分区：
文献类型：
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作者：
Borch-Johnsen, K;Neil, A;Qiao, Q
背景：美国糖尿病协会批准了基于空腹血糖（FBG）水平的糖尿病新诊断标准。仅使用 FBG 的影响尚未得到彻底评估。比较空腹和 2 小时血糖 (2h-BG) 标准对死亡率的预测。方法：分析了 10 项前瞻性欧洲队列研究中空腹和 75 g 口服葡萄糖耐量试验后 2 小时血糖水平的现有基线数据，这些研究包括 15388 名男性和 7126 名女性，年龄在 30 至 89 岁之间，中位随访时间为 8.8 年。估计了全因死亡、心血管疾病、冠心病和中风的风险比。结果：多变量 Cox 回归分析表明，纳入 FBG 并没有为单独 2h-BG 的预测添加显着信息（对于各种原因，P>.10），而在 FBG 标准中添加 2h-BG 显着改善了预测（P
Background: New diagnostic criteria for diabetes based on fasting blood glucose (FBG) level were approved by the American Diabetes Association. The impact of using FBG only has not been evaluated thoroughly. The fasting and the 2-hour glucose (2h-BG) criteria were compared with regard to the prediction of mortality.Methods: Existing baseline data on glucose level at fasting and 2 hours after a 75-g oral glucose tolerance test from 10 prospective European cohort studies including 15388 men and 7126 women aged 30 to 89 years, with a median follow-up of 8.8 years, were analyzed. Hazards ratios for death from all causes, cardiovascular disease, coronary heart disease, and stroke were estimated.Results: Multivariate Cox regression analyses showed that the inclusion of FBG did not add significant information on the prediction of 2h-BG alone (P>.10 for various causes), whereas the addition of 2h-BG to FBG criteria significantly improved the prediction (P