ANTI-DEPRESSANT POTENTIATION OF 5-HYDROXYTRYPTOPHAN BY L-DEPRENIL IN AFFECTIVE-ILLNESS
ANTI-DEPRESSANT POTENTIATION OF 5-HYDROXYTRYPTOPHAN BY L-DEPRENIL IN AFFECTIVE-ILLNESS
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DOI：
10.1016/0165-0327(80)90013-0
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发表时间：
1980-01-01
影响因子：
6.6
通讯作者：
YOUDIM, MBH
中科院分区：
文献类型：
--
作者：
MENDLEWICZ, J;YOUDIM, MBH
L-Deprenil是一种不可逆选择性MAO-B（单胺氧化酶b）抑制剂，无奶酪效应，用于14例接受l -5-羟色氨酸（L-5-HTP）和苯肼治疗的单极和双相抑郁症患者。在14例患者中，10例对联合用药反应良好，血小板MAO抑制程度与临床反应之间存在相关性。在一项双盲对照研究中，18例情感疾病患者被随机分配到l - depreil + L-5-HTP和苯肼组，21例患者接受L-5-HTP和苯肼治疗，19例患者仅接受安慰剂治疗。l - depreil和L-5-HTP联合治疗的患者比安慰剂患者表现出更大的临床改善，但单独接受5-HTP治疗的患者却没有这种情况。l - depreil治疗患者的情绪改善与血小板MAO抑制程度呈正相关。
L-Deprenil, an irreversible selective MAO-B (monoamine oxidase-B) inhibitor without cheese effect was given to 14 patients with unipolar and bipolar depression receiving L-5-hydroxytryptophan (L-5-HTP) and benzerazide. Out of 14 patients 10 showed a good response to the combination of drugs and a correlation was found between the degree of platelet MAO inhibition and clinical response. In a double-blind controlled study, 18 affectively ill patients were randomly allocated to L-deprenil plus L-5-HTP and benzerazide, 21 patients were treated with L-5-HTP and benzerazide and 19 patients with placebo only. Patients treated with the combination of L-deprenil and L-5-HTP showed a significantly greater clinical improvement than placebo patients but this was not the case for patients treated with 5-HTP alone. A positive relationship was demonstrated between mood improvement and degree of platelet MAO inhibition in patients treated with L-deprenil.