Ultradian oscillations of leptin secretion in humans
Ultradian oscillations of leptin secretion in humans
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DOI：
10.1006/bbrc.1996.1724
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发表时间：
1996-11-21
影响因子：
3.1
通讯作者：
Caro, JF
中科院分区：
文献类型：
--
作者：
Sinha, MK;Sturis, J;Caro, JF
We have recently demonstrated the nocturnal increase in leptin secretion in humans. In the present study we have examined the pulsatile pattern of leptin secretion using two different experimental protocols. The first protocol utilized blood samples withdrawn at 30 minute intervals immediately after meals, at 1 hour intervals between meals, and at 2 hour intervals during the night from 4 lean, 11 obese, and 5 obese NIDDM subjects. Analysis of circulating leptin levels by ULTRA algorithmic program and using matched intra-assay coefficient of variations demonstrated 1 to 7 ultradian oscillations with a mean of 3.25 +/- 0.36 (SEM) pulses per 24 hour period (period: 10.0 +/- 1.5 hours; mean relative amplitude: 0.52 +/- 0.06, n=20). Significant positive correlations were observed for changes in absolute amplitude with body mass index (p
