Changes of p53 in the brains of patients with Alzheimer's disease
Changes of p53 in the brains of patients with Alzheimer's disease
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DOI：
10.1006/bbrc.1997.6301
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发表时间：
1997-03-17
影响因子：
3.1
通讯作者：
Taniguchi, T
中科院分区：
文献类型：
--
作者：
Kitamura, Y;Shimohama, S;Taniguchi, T
近年来的研究表明，阿尔茨海默病（Alzheimer's disease，AD）患者大脑皮层神经元和神经胶质细胞发生凋亡。在AD脑中，颞叶皮质中的p53的量显著高于对照组，并且在胶质细胞中观察到这种p53样免疫反应性。这些结果表明，p53可能参与了AD脑胶质细胞的凋亡，但神经元的凋亡可能通过p53非依赖性途径发生。(C)北京：科学出版社.
Recent studies suggest that cortical neurons and glial cells undergo apoptosis in Alzheimer's disease (AD), Since the protein p53 is known to induce apoptosis, we assessed p53 in postmortem samples from normal human and AD brains using specific antibody. In AD brains, the amount of p53 in temporal cortex was significantly higher than in controls, and this p53-like immunoreactivity was observed in glial cells. These findings suggest that the p53 may be involved in the apoptosis of glial cells in AD brains, but apoptosis in neurons may occur through a p53-independent pathway. (C) 1997 Academic Press.