The Chicken Gene Nomenclature Committee report.
The Chicken Gene Nomenclature Committee report.
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DOI：
10.1186/1471-2164-10-s2-s5
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发表时间：
2009-07-14
期刊：
影响因子：
4.4
通讯作者：
McCarthy FM
中科院分区：
文献类型：
--
作者：
Burt DW;Carrë W;Fell M;Law AS;Antin PB;Maglott DR;Weber JA;Schmidt CJ;Burgess SC;McCarthy FM
比较基因组学是后基因组时代的重要组成部分。鸡的基因组是第一个被测序的鸟类基因组，它将作为其他鸟类物种的模型。此外，由于其独特的进化生态位，鸡基因组可以用来了解哺乳动物物种的功能元件和基因调控的进化。然而，由于难以识别功能性直系同源物，鸟类物种内和鸟类内的比较生物学受到阻碍。随着不同的数据库和序列库的激增，以及它们为功能元件指定的名称沿着激增，这个问题变得更加复杂。目前，基因可以用一个以上的名字发表，一个名字有时指的是不相关的基因。标准化的基因命名是必要的，以促进科学家和基因组资源之间的沟通。此外，重要的是，这种命名是基于现有的命名努力，在可能的情况下，真正促进不同物种之间的研究。我们在这里报告的鸡基因命名委员会（CGNC），国际和集中的努力，提供标准化的命名鸡基因的形成。CGNC与NCBI和Ensembl等公共资源合作，并与现有的人类和小鼠命名委员会协商。CGNC将与研究界协商制定标准化的命名法，并依赖研究界的支持，以确保命名法有利于比较和基因组研究。
Comparative genomics is an essential component of the post-genomic era. The chicken genome is the first avian genome to be sequenced and it will serve as a model for other avian species. Moreover, due to its unique evolutionary niche, the chicken genome can be used to understand evolution of functional elements and gene regulation in mammalian species. However comparative biology both within avian species and within amniotes is hampered due to the difficulty of recognising functional orthologs. This problem is compounded as different databases and sequence repositories proliferate and the names they assign to functional elements proliferate along with them. Currently, genes can be published under more than one name and one name sometimes refers to unrelated genes. Standardized gene nomenclature is necessary to facilitate communication between scientists and genomic resources. Moreover, it is important that this nomenclature be based on existing nomenclature efforts where possible to truly facilitate studies between different species. We report here the formation of the Chicken Gene Nomenclature Committee (CGNC), an international and centralized effort to provide standardized nomenclature for chicken genes. The CGNC works in conjunction with public resources such as NCBI and Ensembl and in consultation with existing nomenclature committees for human and mouse. The CGNC will develop standardized nomenclature in consultation with the research community and relies on the support of the research community to ensure that the nomenclature facilitates comparative and genomic studies.