CLINICAL UTILITY OF SALIVARY LITHIUM CONCENTRATION
CLINICAL UTILITY OF SALIVARY LITHIUM CONCENTRATION
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DOI：
10.1159/000468563
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
CLOTHIER, JM
中科院分区：
文献类型：
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作者：
BOWDEN, CL;HOUSTON, JP;CLOTHIER, JM
本文对40例长期服用锂剂者的唾液、血浆和红细胞锂浓度进行了研究。当基于组线性回归方程时，唾液与血浆Li比率的受试者间差异对于临床实用性来说太大。在3个或更多场合研究的8名患者的受试者内数据表明较高的线性相关性（7/8名患者r = 0.91-1.00）。对于个体患者，该比值在不同浓度范围内保持稳定，并且不受末次给药时间或使用Li时间的影响。在获得几种血液和唾液浓度以建立特定患者的关系之后，使用Li的唾液浓度进行常规监测似乎是可行的。唾液监测可以促进准确的分析和方便一些患者。
Saliva, plasma and erythrocyte Li concentrations were studied in 40 long-term Li users. Intersubject variation in saliva to plasma Li ratio was too great for clinical utility, when based on a group linear regression equation. Intrasubject data from 8 patients studied on 3 or more occasions indicated a higher linear correlation (r = 0.91-1.00 for 7 of 8 patients). For individual patients the ratio remained stable over varying concentration ranges and was not affected by time from last dose or length of use of Li. Use of saliva concentrations of Li for routine monitoring appears feasible after several blood and saliva concentrations are obtained to establish a relationship for a particular patient. Saliva monitoring may facilitate accurate analysis and convenience for some patients.