Executive dysfunction and memory impairment in schizoaffective disorder: a comparison with bipolar disorder, schizophrenia and healthy controls
Executive dysfunction and memory impairment in schizoaffective disorder: a comparison with bipolar disorder, schizophrenia and healthy controls
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DOI：
10.1017/s0033291712000104
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发表时间：
2012-10-01
影响因子：
6.9
通讯作者：
Pomarol-Clotet, E.
中科院分区：
文献类型：
--
作者：
Amann, B.;Gomar, J. J.;Pomarol-Clotet, E.
背景。记忆和执行能力的缺陷是公认的双相情感障碍和精神分裂症的特征。相比之下，关于精神分裂情感障碍的认知障碍的数据很少，研究结果也很矛盾。我们使用韦氏记忆量表（WMS-III）和执行障碍综合征行为评估（BADS）来测试45名精神分裂症患者、26名精神分裂症患者和51名躁狂双相患者的记忆和执行功能，并与65名健康对照者进行比较。患者急性发病时进行检测。所有三组患者在记忆和执行功能的整体测量上的表现都明显比对照组差，但两组患者之间没有差异。两组患者在记忆和执行功能亚测试得分上差异不大。有精神症状和无精神症状的躁狂患者在任何测试分数上没有差异。精神分裂症、精神分裂症和躁狂患者在疾病的急性期表现出大致相似程度的执行和记忆缺陷。我们的结果不支持关于神经心理缺陷的不同精神病类别的分类分化。
Background. Deficits in memory and executive performance are well-established features of bipolar disorder and schizophrenia. By contrast, data on cognitive impairment in schizoaffective disorder are scarce and the findings are conflicting.Method. We used the Wechsler Memory Scale (WMS-III) and the Behavioural Assessment of the Dysexecutive Syndrome (BADS) to test memory and executive function in 45 schizophrenic patients, 26 schizomanic patients and 51 manic bipolar patients in comparison to 65 healthy controls. The patients were tested when acutely ill.Results. All three patient groups performed significantly more poorly than the controls on global measures of memory and executive functioning, but there were no differences among the patient groups. There were few differences in memory and executive function subtest scores within the patient groups. There were no differences in any test scores between manic patients with and without psychotic symptoms.Conclusions. Schizophrenic, schizomanic and manic patients show a broadly similar degree of executive and memory deficits in the acute phase of illness. Our results do not support a categorical differentiation across different psychotic categories with regard to neuropsychological deficits.