Controlling the spontaneous spiking regularity via channel blocking on Newman-Watts networks of Hodgkin-Huxley neurons
Controlling the spontaneous spiking regularity via channel blocking on Newman-Watts networks of Hodgkin-Huxley neurons
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DOI：
10.1209/0295-5075/86/40008
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发表时间：
2009-05-01
期刊：
影响因子：
1.8
通讯作者：
Uzuntarla, Muhammet
中科院分区：
文献类型：
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作者：
Ozer, Mahmut;Perc, Matjaz;Uzuntarla, Muhammet
我们研究了Newman-Watts小世界网络的自发放电活动的规律，该网络由生物物理上真实的Hodgkin-Huxley神经元组成，其本征噪声强度可调，神经元膜上嵌入了部分被阻断的电压门控钠离子和钾离子通道。我们表明，在物理上遥远的神经元之间存在最优比例的捷径连接，以及最优的本征噪声强度，这保证了最优有序的自发放电活动。这种双相干共振现象在很大程度上取决于关闭的钠离子和钾离子通道的比例，并且可以通过这些比例进行控制，因此可以通过分析来了解影响。振铃速率函数以及确定性系统动力学。我们的发现对通过神经网络传播信息的潜在生物学意义也进行了讨论。版权所有(C)Epla，2009
We investigate the regularity of spontaneous spiking activity on Newman-Watts small-world networks consisting of biophysically realistic Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise and fraction of blocked voltage-gated sodium and potassium ion channels embedded in neuronal membranes. We show that there exists an optimal fraction of shortcut links between physically distant neurons, as well as an optimal intensity of intrinsic noise, which warrant an optimally ordered spontaneous spiking activity. This doubly coherence resonance-like phenomenon depends significantly on, and can be controlled via, the fraction of closed sodium and potassium ion channels, whereby the impacts can be understood via the analysis of the. ring rate function as well as the deterministic system dynamics. Potential biological implications of our findings for information propagation across neural networks are also discussed. Copyright (C) EPLA, 2009