Making sense of the sensory regulation of hunger neurons.
Making sense of the sensory regulation of hunger neurons.
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DOI：
10.1002/bies.201500167
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Knight ZA
中科院分区：
文献类型：
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作者：
Chen Y;Knight ZA
AgRP和POMC神经元是调节摄食的两种关键细胞类型，它们对激素和营养做出反应。最近，人们发现，仅仅是看到和闻到食物，这些神经元也会迅速调制。这种快速的感觉调节会在一口食物被吃掉之前“重置”AgRP和POMC神经元的活动。这一令人惊讶和违反直觉的发现挑战了长期以来关于这些细胞的功能和调节的假设。在这里，我们回顾了这些最新的发现，并讨论了它们对我们理解摄食行为的影响。对于如何将这些新的观察结果整合到一个修正的馈电回路模型中，我们提出了几个替代的假设，并强调了一些有待回答的关键问题。
AgRP and POMC neurons are two key cell types that regulate feeding in response to hormones and nutrients. Recently, it was discovered that these neurons are also rapidly modulated by the mere sight and smell of food. This rapid sensory regulation “resets” the activity of AgRP and POMC neurons before a single bite of food has been consumed. This surprising and counterintuitive discovery challenges longstanding assumptions about the function and regulation of these cells. Here we review these recent findings and discuss their implications for our understanding of feeding behavior. We propose several alternative hypotheses for how these new observations might be integrated into a revised model of the feeding circuit, and also highlight some of the key questions that remain to be answered.