Survival following stroke.
Survival following stroke.
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中风后的生存率。
DOI：
10.1001/jama.1963.03700110053010
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发表时间：
1963
期刊：
影响因子：
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通讯作者：
H. Richard Tyler
中科院分区：
文献类型：
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作者：
Frank A. Howard;Phin Cohen;R. Hickler;Simeon Locke;Thomas Newcomb;H. Richard Tyler
在这项对100名非出血性中风(“脑血栓”)成人患者的3年随访研究中，发现死亡率与年龄几乎呈线性相关。尽管年龄分布相同，但在同一时期，血压正常组(收缩压低于140毫米汞柱)的死亡率为30%，而血压较高组的死亡率约为50%。疾病的复杂化显著增加了死亡率。在两位神经学家看过的70名患者中，以及他们和一个研究小组看过的30名患者中，评估了抗凝剂的作用。这项研究是对照的，评价是双盲的。两组患者均未观察到抗凝治疗的益处。这种疗法的禁忌症和困难是可怕的。结论：在大多数脑血栓形成患者中，不建议使用抗凝治疗。
In this 3-yr follow-up study of 100 adult patients with nonhemorrhagic strokes ("cerebral thrombosis"), mortality was found to be almost linearly related to age. Despite an identical age distribution, the normotensive group (systolic BP below 140 mm Hg) had a mortality of 30%, while those with higher BP had approximately a 50% mortality rate during the same period. Complicating diseases strikingly increased mortality. In 70 patients seen by two neurologists, and in 30 patients seen by them and by a study team, the role of anticoagulants was evaluated. The study was controlled and evaluation was doubleblind. No benefit from anticoagulant therapy was noted in either group. The contraindications to and difficulties with this therapy were formidable. It was concluded that use of anticoagulant therapy is not indicated in the majority of patients with cerebral thrombosis.