Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
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发表时间：
2001
期刊：
影响因子：
82.9
通讯作者：
R. L. Tuttle;N. S. Gill;W. Pugh;J. P. Lee;B. Koeberlein;E. Furth;K. Polonsky;A. Naji;M. Birnbaum
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作者：
R. L. Tuttle;N. S. Gill;W. Pugh;J. P. Lee;B. Koeberlein;E. Furth;K. Polonsky;A. Naji;M. Birnbaum
器官的生理性能取决于细胞功能和器官大小变化之间的相互作用，而器官大小又由细胞生长、增殖和死亡决定。这一点在内分泌胰腺中最为明显，其中功能或质量的紊乱会导致严重的疾病。最近，胰岛素信号转导途径与哺乳动物β细胞激素分泌的调节以及果蝇细胞和器官大小的确定有关。胰岛素和胰岛素样生长因子 1 (IGF-1) 作用的一个重要介质是 3'-磷酸肌醇依赖性蛋白激酶 Akt，也称为蛋白激酶 B (PKB)。在这里，我们报告活性 Akt1 在小鼠 β 细胞中的过度表达显着影响区室大小和功能。 β细胞大小和胰岛总质量显着增加，同时葡萄糖耐量改善，对实验性糖尿病完全抵抗。
The physiological performance of an organ depends on an interplay between changes in cellular function and organ size, determined by cell growth, proliferation and death. Nowhere is this more evident than in the endocrine pancreas, where disturbances in function or mass result in severe disease. Recently, the insulin signal-transduction pathway has been implicated in both the regulation of hormone secretion from beta cells in mammals as well as the determination of cell and organ size in Drosophila melanogaster. A prominent mediator of the actions of insulin and insulin-like growth factor 1 (IGF-1) is the 3'-phosphoinositide-dependent protein kinase Akt, also known as protein kinase B (PKB). Here we report that overexpression of active Akt1 in the mouse beta cell substantially affects compartment size and function. There was a significant increase in both beta-cell size and total islet mass, accompanied by improved glucose tolerance and complete resistance to experimental diabetes.