Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior.
Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior.
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DOI：
10.1016/j.expneurol.2016.01.018
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发表时间：
2016-04
影响因子：
5.3
通讯作者：
Savage LM
中科院分区：
文献类型：
--
作者：
Hall JM;Savage LM
运动已被证明可以改善一系列物种的认知功能，可能是通过增加整个大脑中的神经营养素，尤其是海马体。目前的研究评估了运动对由吡硫胺诱导的硫胺缺乏(PTD)大鼠记忆障碍Korsakoff综合征模型隔海马胆碱能功能恢复的能力。在自愿跑轮或静坐控制条件(固定轮子固定在家笼上)后，PTD和对照组大鼠在两个时间点之一：运动后24小时或2周，同时进行体内微透析的行为学测试。研究发现，只有在2周的适应期后，运动才能导致PTD大鼠一系列相互关联的事件，包括：(1)恢复空间工作记忆；(2)挽救行为刺激的海马乙酰胆碱外流；(3)在内侧隔/斜角带内，胆碱能(胆碱乙酰转移酶[ChAT+])表型重新出现，其中ChAT+/Nestin+神经元的变化最大。此外，在对照组大鼠中，运动后2周的适应期改善了海马乙酰胆碱的外流，并增加了共同表达ChAT和Nestin表型的神经元的数量。这些发现证明了一种新的机制，即运动可以调节成熟的胆碱能/巢蛋白神经元表型，从而改善神经递质功能，并增强学习和记忆。
Exercise has been shown to improve cognitive functioning in a range of species, presumably through an increase in neurotrophins throughout the brain, but in particular the hippocampus. The current study assessed the ability of exercise to restore septohippocampal cholinergic functioning in the pyrithiamine-induced thiamine deficiency (PTD) rat model of the amnestic disorder Korsakoff Syndrome. After voluntary wheel running or sedentary control conditions (stationary wheel attached to the home cage), PTD and control rats were behaviorally tested with concurrent in vivo microdialysis, at one of two time points: 24-hrs or 2-wks post-exercise. It was found that only after the 2-wk adaption period did exercise lead to an interrelated sequence of events in PTD rats that included: (1) restored spatial working memory; (2) rescued behaviorally-stimulated hippocampal acetylcholine efflux; and (3) within the medial septum/diagonal band, the reemergence of the cholinergic (choline acetyltransferase [ChAT+]) phenotype, with the greatest change occurring in the ChAT+/nestin+ neurons. Furthermore, in control rats, exercise followed by a 2-wk adaption period improved hippocampal acetylcholine efflux and increased the number of neurons co-expressing the ChAT and nestin phenotype. These findings demonstrate a novel mechanism by which exercise can modulate the mature cholinergic/nestin neuronal phenotype leading to improved neurotransmitter function as well as enhanced learning and memory.