SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants.
SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants.
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SUMO介导的转录因子调控是植物将环境信号转导为细胞信号的机制。
DOI：
10.1007/s00018-020-03723-4
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Sadanandom A
中科院分区：
文献类型：
--
作者：
Roy D;Sadanandom A
在所有物种中，转录因子(TF)是SUMO化最常见的靶标。相扑结合对转录因子功能的影响已经在动物系统中得到了广泛的研究，已有200多个转录因子被证明受SUMO化调控。这导致了一些范式的建立，这些范式试图解释相扑调节转录因子功能的机制。例如，相扑已被证明可以调节TFDNA结合活性；调节TFs的定位和丰度，并影响TFs与染色质的结合。随着转录因子被认为是所有生物体中维持表型可塑性的细胞信号通路的主要调节因子，在本综述中，我们将讨论相扑介导的转录因子活性的调节如何促进分子通路对环境提示做出适当和连贯的生物反应。
Across all species, transcription factors (TFs) are the most frequent targets of SUMOylation. The effect of SUMO conjugation on the functions of transcription factors has been extensively studied in animal systems, with over 200 transcription factors being documented to be modulated by SUMOylation. This has resulted in the establishment of a number of paradigms that seek to explain the mechanisms by which SUMO regulates transcription factor functions. For instance, SUMO has been shown to modulate TF DNA binding activity; regulate both localization as well as the abundance of TFs and also influence the association of TFs with chromatin. With transcription factors being implicated as master regulators of the cellular signalling pathways that maintain phenotypic plasticity in all organisms, in this review, we will discuss how SUMO mediated regulation of transcription factor activity facilitates molecular pathways to mount an appropriate and coherent biological response to environmental cues.
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影响因子：
7.4
作者：
Cheong, Mi Sun;Park, Hyeong Cheol;Yun, Dae-Jin
通讯作者：
Yun, Dae-Jin
影响因子：
11.6
作者：
CAO, H;BOWLING, SA;DONG, XN
通讯作者：
DONG, XN
DOI：
10.1042/bj20101446
发表时间：
2011-06-15
期刊：
The Biochemical journal
影响因子：
--
作者：
Castaño-Miquel L;Seguí J;Lois LM
通讯作者：
Lois LM
影响因子：
11.6
作者：
Catala, Rafael;Ouyang, Jian;Chua, Nam-Hai
通讯作者：
Chua, Nam-Hai
影响因子：
11.6
作者：
Achard, Patrick;Gong, Fan;Genschik, Pascal
通讯作者：
Genschik, Pascal