Deaminative Reductive Arylation Enabled by Nickel/Photoredox Dual Catalysis
Deaminative Reductive Arylation Enabled by Nickel/Photoredox Dual Catalysis
复制标题
镍/光氧化还原双重催化实现脱氨基还原芳基化
DOI：
10.1021/acs.orglett.9b01097
复制
发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
er Gary A
中科院分区：
文献类型：
--
作者：
Yi Jun;Badir Shorouk O;Kammer Lisa Marie;Ribagorda Maria;Mol;er Gary A
介绍了一种利用Katritzky盐作为镍/光氧化还原双重催化还原交叉偶联反应中一种新的亲电试剂的交叉亲电、脱氨基偶联策略。这种芳基化方案的特点包括反应条件温和，化学选择性高，对各种复杂底物的适应性[例如，来自胺的吡啶盐和来自(杂)芳基溴化物的伙伴]。
Described is a cross-electrophilic, deaminative coupling strategy harnessing Katritzky salts as a new species of electrophile in Ni/photoredox dual catalytic reductive cross-coupling reactions. Distinguishing features of this arylation protocol include its mild reaction conditions, high chemoselectivity, and adaptability to a variety of complex substrates [i.e., pyridinium salts derived from amines and partners derived from (hetero)aryl bromides].