Insulin levels control female germline stem cell maintenance via the niche in Drosophila
Insulin levels control female germline stem cell maintenance via the niche in Drosophila
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DOI：
10.1073/pnas.0809144106
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发表时间：
2009-01-27
影响因子：
11.1
通讯作者：
Drummond-Barbosa, Daniela
中科院分区：
文献类型：
--
作者：
Hsu, Hwei-Jan;Drummond-Barbosa, Daniela
干细胞的维持依赖于它们所在的特殊微环境或利基环境提供的局部信号。然而，系统性因素在干细胞维持中的潜在作用在很大程度上仍未被探索。在这里，我们表明，胰岛素信号整合了饮食和年龄对生殖系干细胞(GSC)维持的影响，通过帽细胞数量的双重调节(通过Notch信号)和帽细胞-GSC的相互作用(通过E-钙粘素)，随着年龄的增加，GSC的正常过程和利基细胞的丢失可以被胰岛素样肽水平的增加所抑制。这些结果强调了系统性因素对干细胞生态位调控的重要性，从而也强调了干细胞数量调控的重要性。
Stem cell maintenance depends on local signals provided by specialized microenvironments, or niches, in which they reside. The potential role of systemic factors in stem cell maintenance, however, has remained largely unexplored. Here, we show that insulin signaling integrates the effects of diet and age on germline stem cell (GSC) maintenance through the dual regulation of cap cell number (via Notch signaling) and cap cell-GSC interaction (via E-cadherin) and that the normal process of GSC and niche cell loss that occurs with age can be suppressed by increased levels of insulin-like peptides. These results underscore the importance of systemic factors for the regulation of stem cell niches and, thereby, of stem cell numbers.