A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
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DOI：
10.1056/nejmoa022363
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发表时间：
2003-10-09
影响因子：
158.5
通讯作者：
Poulton, R
中科院分区：
文献类型：
--
作者：
Sears, MR;Greene, JM;Poulton, R
背景：成人儿童哮喘的结局已在高危人群中得到描述，但很少有基于人群的研究报告持续存在和复发的危险因素。方法：我们对 1972 年 4 月至 1973 年 3 月出生于新西兰但尼丁的儿童进行了反复评估，从 9 岁到 26 岁，进行了问卷调查、肺功能测试、支气管挑战测试和过敏测试。结果：到 26 岁时，在 613 名拥有完整呼吸数据的研究成员中，有 51.4% 在不止一次评估中报告有喘息。 89 名研究成员 (14.5%) 的喘息症状从童年一直持续到 26 岁，而 168 人 (27.4%) 的喘息症状得到缓解，但 76 人 (12.4%) 随后在 26 岁时复发。对屋尘螨的敏感性可预测喘息的持续性（优势比，2.41；P=0.001）和复发（优势比）比率，2.18；P=0.01），气道高反应性也是如此（持续优势比，3.00；P
BACKGROUND:The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse.METHODS:We assessed children born from April 1972 through March 1973 in Dunedin, New Zealand, repeatedly from 9 to 26 years of age with questionnaires, pulmonary-function tests, bronchial-challenge testing, and allergy testing.RESULTS:By the age of 26 years, 51.4 percent of 613 study members with complete respiratory data had reported wheezing at more than one assessment. Eighty-nine study members (14.5 percent) had wheezing that persisted from childhood to 26 years of age, whereas 168 (27.4 percent) had remission, but 76 (12.4 percent) subsequently relapsed by the age of 26. Sensitization to house dust mites predicted the persistence of wheezing (odds ratio, 2.41; P=0.001) and relapse (odds ratio, 2.18; P=0.01), as did airway hyperresponsiveness (odds ratio for persistence, 3.00; P