Schizotaxia, schizotypy, and schizophrenia: Paul E. Meehl's blueprint for the experimental psychopathology and genetics of schizophrenia
Schizotaxia, schizotypy, and schizophrenia: Paul E. Meehl's blueprint for the experimental psychopathology and genetics of schizophrenia
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DOI：
10.1037/0021-843x.115.2.195
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发表时间：
2006-05-01
影响因子：
4.6
通讯作者：
Lenzenweger, Mark F.
中科院分区：
文献类型：
--
作者：
Lenzenweger, Mark F.
保罗·E·梅尔在20世纪60年代初提出了精神分裂症和相关状态的病因和发病机制的模型(Meehl，1962)，后来他在1990年进行了修订(Meehl，1990)。他的模型强调了神经传递中的一种受基因影响的异常，这种异常可能最终出现在临床精神分裂症、非精神病型分裂状态，或者取决于其他因素共存的明显正常状态。他的模型体现了素质-压力源框架的核心思想，该框架将在未来40年主导实验和发展精神病理学。作者回顾了Meehl关于分裂倾向、分裂类型和精神分裂症的模型，并回顾和澄清了对该模型的一些常见的误解。
Paul E. Meehl proposed a model of the cause and pathogenesis of schizophrenia and related states in the early 1960s (Meehl, 1962), which he later revised in 1990 (Meehl, 1990). His model emphasized a genetically influenced aberration in neural transmission that could eventuate in clinical schizophrenia, nonpsychotic schizotypic states, or apparent normalcy depending on the coexistence of other factors. His model embodied the core ideas of the diathesis-stressor framework that would come to dominate experimental and developmental psychopathology for the next 40 years. The author reviews Meehl's model of schizotaxia, schizotypy, and schizophrenia and reviews and clarifies some frequent misunderstandings of the model.