Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics.
Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics.
复制标题
新移民和旅行者评估（Asante）试验的监视和阿奇霉素治疗：设计和基线特征。
DOI：
10.1080/09286586.2016.1238947
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发表时间：
2016-12
影响因子：
1.8
通讯作者：
West SK
中科院分区：
文献类型：
--
作者：
Ervin AM;Mkocha H;Munoz B;Dreger K;Dize L;Gaydos C;Quinn TC;West SK
在接近消除沙眼的沙眼流行社区，移民和旅行者可能是再次出现感染的来源。A监测和阿奇霉素治疗的新来者和旅行者评价（ASANTE）试验的主要目的是确定是否新来者和旅行者的监测和治疗计划，除了每年的大规模药物管理（MDA）将减少沙眼衣原体感染相比，MDA单独。ASANTE是在坦桑尼亚Kongwa的52个社区进行的随机对照试验。在26个干预社区，监测人员对新住户中的每一个人、新来的儿童和现有住户中的监护人以及在年度MDA活动之间旅行的住户中的所有人进行了治疗。26个惯常做法社区仅收到MDA。在基线和每6个月至2年对每个社区的100名1-9岁儿童进行调查，以评估临床沙眼和沙眼衣原体感染。还收集了关于人口统计和环境因素的数据。两组间的沙眼性滤泡性炎症（TF）和沙眼衣原体的平均患病率相当（干预组分别为5.2%和3.7%，常规治疗组分别为4.9%和3.6%）。在318名TF患儿中，36.5%的沙眼衣原体检测阳性。无自行车家庭TF患病率较高（P=0.03），随儿童年龄增长TF患病率降低（P<0.001）。距离水源30分钟以上的家庭感染率较高（P=0.015）。TF和感染率随受教育年限的增加而降低（分别为P=0.004和P=0.002）。ASANTE试验将为旅行或新到达沙眼低流行社区的人员的监测和治疗提供指导。
Immigrants and travelers may be sources of re-emergent infection in trachoma-endemic communities close to trachoma elimination. The primary objective of the A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) trial was to determine whether a newcomer and traveler surveillance and treatment program in addition to annual mass drug administration (MDA) would reduce Chlamydia trachomatis infection when compared to MDA alone. ASANTE was a randomized controlled trial in 52 communities in Kongwa, Tanzania. In 26 intervention communities, monitors treated everyone in new households, in-coming children and guardians in existing households, and all persons in households who had travelled between annual MDA events. 26 usual practice communities received MDA only. Surveys of 100 1-9-year-olds from each community were conducted at baseline and every 6 months up to 2 years to assess clinical trachoma and C trachomatis infection. Data on demographics and environmental factors were also collected. Mean prevalences of trachomatous inflammation - follicular (TF) and C trachomatis were equivalent between the two arms (5.2% and 3.7% in intervention, and 4.9% and 3.6% in usual practice communities, respectively). Of 318 children with TF, 36.5% tested positive for C trachomatis. TF prevalence was higher among households without a bicycle (P=0.03) and lower with increasing child’s age (P<0.001). Infection prevalence was higher among households >30 minutes from water (P=0.015). TF and infection prevalence decreased with increasing years of education (P=0.004 and P=0.002, respectively). The ASANTE trial will inform guidance on the surveillance and treatment of persons traveling or newly arriving to communities hypo-endemic for trachoma.