A prospective study comparing tendon-to-bone interface healing using an interposition bioresorbable scaffold with a vented anchor for primary rotator cuff repair in sheep
A prospective study comparing tendon-to-bone interface healing using an interposition bioresorbable scaffold with a vented anchor for primary rotator cuff repair in sheep
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DOI：
10.1016/j.jse.2019.05.024
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发表时间：
2020-01-01
影响因子：
3
通讯作者：
McGilvray, Kirk
中科院分区：
文献类型：
--
作者：
Easley, Jeremiah;Puttlitz, Christian;McGilvray, Kirk
背景资料：本研究的目的是评价肩袖修复术的生物力学和组织学特性，该修复术使用连接到由对齐的PLGA组成的生物可吸收间置支架上的通气型锚在动物模型中使用聚（L-丙交酯-共-糖苷）微纤维与绵羊模型中的标准锚钉进行比较。将五十六（n = 56）只成年绵羊随机分配至使用创新锚-PLGA支架装置修复急性冈下肌肌腱脱离的实验组（治疗）或类似的没有支架的锚（对照）。在修复后7周和12周对动物实施人道处死。修复的组织学和生物力学性能进行了评估和compared.Results：治疗组有一个显着较高的成纤维细胞计数在7周相比，对照组。12周时，治疗组的肌腱骨修复距离、垂直纤维百分比、肌腱-骨界面新骨形成和III型胶原沉积均显著大于对照组（P.05）.结论：使用连接到由对齐的PLGA微纤维组成的生物可吸收间置支架的通气锚改善了肩袖修复的组织学特性，绵羊模型在12周时间点，组织学改善与最终结构强度改善相关。(C)2019作者爱思唯尔公司出版代表肩肘外科杂志董事会。
Background: The purpose of this study was to evaluate the biomechanical and histologic properties of rotator cuff repairs using a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA (poly(L-lactide-co-glycoside)) microfibers in an animal model compared to standard anchors in an ovine model.Methods: Fifty-six (n = 56) skeletally mature sheep were randomly assigned to a repair of an acute infraspinatus tendon detachment using a innovative anchor-PLGA scaffold device (Treatment) or a similar anchor without the scaffold (Control). Animals were humanely euthanized at 7 and 12 weeks post repair. Histologic and biomechanical properties of the repairs were evaluated and compared.Results: The Treatment group had a significantly higher fibroblast count at 7 weeks compared to the Control group. The tendon bone repair distance, percentage perpendicular fibers, new bone formation at the tendon-bone interface, and collagen type III deposition was significantly greater for the Treatment group compared with the Control group at 12 weeks (P .05).Conclusions: Use of a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA microfibers improves the histologic properties of rotator cuff repairs in a sheep model. Improved histology was correlated with improved final construct strength at the 12-week time point. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of Journal of Shoulder and Elbow Surgery Board of Trustees.