REVERSIBILITY OF CHRONIC OBSTRUCTIVE LUNG-DISEASE IN INFANTS FOLLOWING REPAIR OF VENTRICULAR SEPTAL-DEFECT
REVERSIBILITY OF CHRONIC OBSTRUCTIVE LUNG-DISEASE IN INFANTS FOLLOWING REPAIR OF VENTRICULAR SEPTAL-DEFECT
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DOI：
10.1016/s0022-3476(77)80627-6
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发表时间：
1977-01-01
影响因子：
5.1
通讯作者：
STEEG, CN
中科院分区：
文献类型：
--
作者：
HORDOF, AJ;MELLINS, RB;STEEG, CN
10例室间隔缺损和大的左向右分流的婴儿的临床过程中阻塞性肺病的迹象占主导地位。这些患者的气道阻塞可归因于由于肺动脉或心腔扩大压迫导致的大气道阻力增加，以及由于细支气管周围液体积聚导致的小气道阻力增加。在室间隔缺损的心脏直视手术修复后，阻塞性气道疾病的体征迅速消退，表明在这些婴儿中观察到的肺部疾病是继发于室间隔缺损，而不是原发过程。对难治性患者最有效的治疗方法是心脏直视手术修复缺损。
The signs of obstructive lung disease dominated the clinical course of 10 infants with ventricular septal defects and large left-to-right shunts. Airway obstruction in these patients can be attributed to increase in large airway resistance as the result of compression by enlarged pulmonary arteries or cardiac chambers and to increase in small airway resistance as the result of accumulation of peribronchiolar fluid. The rapid regression of the signs of obstructive airway disease following open heart repair of the ventricular septal defect indicates that the lung disease observed in these infants is secondary to the ventricular septal defect, rather than a primary process. The most effective management in the refractory patient is that of open heart repair of the defect.