Atrial Fibrillation: Its Prevalence and Risk Factor Profile in the German General Population
Atrial Fibrillation: Its Prevalence and Risk Factor Profile in the German General Population
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DOI：
10.3238/arztebl.2012.0293
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发表时间：
2012-04-20
影响因子：
7.7
通讯作者：
Blankenberg, Stefan
中科院分区：
文献类型：
--
作者：
Schnabel, Renate B.;Wilde, Sandra;Blankenberg, Stefan
背景资料：心房颤动（AF）是一个越来越常见的问题，在初级保健，但鲜为人知的是，其患病率和分布的AF危险因素在一般population.Methods：我们确定了AF的患病率和分布的已知AF危险因素之间的人参与人口为基础的古滕贝格健康研究。为此，我们使用了5000名年龄在35至74岁之间的人的房颤医疗诊断和心电图（ECG）的访谈数据。结果：研究样本中有5000人（年龄52.2 ± 11岁; 50.6%为女性）。根据一般人群的年龄和性别分布加权的AF患病率为2.5%。发现AF在老年人中更常见，男性中的增加更明显：35- 44岁男性的患病率为0.7%，而65- 74岁年龄组的相应数字高达10.6%。25名参与者（15.5%的AF病例）根据研究ECG接受了AF的初步诊断。与无AF的人相比，AF患者年龄较大，男性更常见，心血管危险因素负担更高。14.3%的房颤患者没有明确的房颤风险因素（收缩压、降压药物、体重指数增加、心力衰竭）。42.7%的人与AF没有服用抗凝剂或血小板inhibitors.Conclusion：这些数据表明，AF的患病率在中年一般人群是2.5%的整体，和更高的老年人。因此，AF是一个重要的公共卫生问题，需要提高对它的认识。
Background: Atrial fibrillation (AF) is an increasingly common problem in primary care, but little is known about its prevalence and the distribution of AF risk factors in the general population.Methods: We determined the prevalence of AF and the distribution of known AF risk factors among persons participating in the population-based Gutenberg Health Study. To this end, we used interview data about the medical diagnosis of AF and electrocardiograms (ECGs) that were performed for the study in 5000 persons aged 35 to 74. The response rate was 60.4%.Results: There were 5000 persons in the study sample (age 52.2 +/- 11 years; 50.6% were women). The prevalence of AF, weighted for the age and sex distribution of the general population, was 2.5%. AF was found to be more common in older persons, with a more pronounced increase in men: whereas its prevalence was 0.7% in 35- to 44-year-old men, the corresponding figure for the age group 65- to 74 was as high as 10.6%. Twenty five participants (15.5% of AF cases) received their initial diagnosis of AF on the basis of the study ECG. Compared to persons without AF, persons with AF were older and more commonly male, and they had a higher burden of cardiovascular risk factors. 14.3% of persons with AF had none of the well-established risk factors for AF (systolic blood pressure, antihypertensive medication, increased body-mass-index, heart failure). 42.7% of persons with AF were not taking either anticoagulants or platelet inhibitors.Conclusion: These data indicate that the prevalence of AF in the middle-aged general population is 2.5% overall, and higher in the elderly. AF is thus a significant public health problem, and greater awareness of it is needed.