Inheritance of susceptibility to root resorption associated with orthodontic force in mice
Inheritance of susceptibility to root resorption associated with orthodontic force in mice
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DOI：
10.1016/j.ajodo.2007.04.035
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发表时间：
2008-12-01
影响因子：
3
通讯作者：
Roberts, W. Eugene
中科院分区：
文献类型：
--
作者：
Abass, Shaza K.;Hartsfield, James K., Jr.;Roberts, W. Eugene
根尖外吸收(EARR)是正畸治疗的后遗症。遗传因素约占人类EARR变异的%。近交系小鼠提供了一个控制环境因素和遗传异质性的模型，这些因素和遗传异质性使人类遗传学研究复杂化。分析了遗传不同的近交系小鼠及其后代(F1)的遗传方式以及亲代性别对正畸力相关牙根吸收(RRAOF)敏感性的影响。方法：对A/J、DBA/2J、BALB/CJ品系雄性和雌性小鼠以及A/J×DBA/2J和A/J×BALB/CJ杂交小鼠(雌雄各10只/正反交)的RRAOF进行组织学测定。将上颌第一磨牙向近中倾斜9d，诱导RRAOF。结果：只有BALB/CJ品系小鼠存在性别差异。A/J×BALB/CJ组合的F_1代表现抗病，表明A/J代具有显性抗病等位基因。而A/J×DBA/2J杂交F1的RRAOF介于其亲本小鼠之间，为多基因性状。结论：这些结果为影响小鼠RRAOF的可追踪和多基因成分提供了证据。(Am J Orthod DentofaceOrthop 2008；134：742-50)
External apical root resorption (EARR) is an unwanted sequelae of orthodontic treatment. Genetic factors account for approximately 64% of the EARR variation in humans. Inbred mice offer a model to control the environmental factors and genetic heterogeneity that complicate human genetic studies. Genetically distinct inbred mice and their offspring (F1s) were analyzed to examine the mode of inheritance and the influence of parental sex on the susceptibility to root resorption associated with orthodontic force (RRAOF). Methods: RRAOF was determined histologically for male and female mice of the A/J, DBA/2J, and BALB/cJ strains, and the A/J x DBA/2J and A/J x BALB/cJ crosses (10 males and 10 females/reciprocal cross). RRAOF was induced by tipping the maxillary first molar mesially for 9 days. Results: Sex differences were observed only among the mice of the BALB/cJ strain. Two patterns of inheritance were observed; F1s from the A/J x BALB/cJ cross were resistant, suggesting that the A/J have dominant resistance alleles. On the other hand, F1s from the A/J x DBA/2J cross showed RRAOF intermediate between their parental mice, suggesting a polygenic trait. Conclusions: These results provide evidence of a traceable and polygenetic component affecting RRAOF in mice. (Am J Orthod Dentofacial Orthop 2008; 134: 742-50)