Neuropsychological Functioning in Parkinson's Disease: Differential Relationships with Self-Reported Sleep-Wake Disturbances
Neuropsychological Functioning in Parkinson's Disease: Differential Relationships with Self-Reported Sleep-Wake Disturbances
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DOI：
10.1002/mds.23640
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发表时间：
2011-07-01
影响因子：
8.6
通讯作者：
Lewis, Simon J. G.
中科院分区：
文献类型：
--
作者：
Naismith, Sharon L.;Terpening, Zoe;Lewis, Simon J. G.
背景：睡眠障碍可能是帕金森病患者发生痴呆的危险因素。然而，以前的研究探索之间的联系，具体的睡眠-觉醒障碍和神经心理functions.Methods：在这项研究中，101例原发性帕金森病患者进行了评估，神经心理测试，并完成了自我报告的问卷调查，包括夜间干扰，白天过度嗜睡，和症状的快速眼动睡眠行为障碍。单变量相关性揭示了与夜间睡眠障碍、白天过度嗜睡和快速眼动睡眠行为障碍相关的神经心理学表现的差异模式。在控制了潜在的混杂因素后，白天过度嗜睡仍然是处理速度减慢的重要预测因素，快速眼动睡眠行为障碍预测了工作记忆和语言流畅性表现。夜间睡眠障碍和记忆之间的关系似乎是介导的education.Conclusions：这些研究结果突出了关键作用，具体的睡眠-觉醒障碍在帕金森病可能有神经心理功能，这可能反映了共同的神经基础。(C)2011年运动障碍学会
Background: Sleep disturbance may represent a risk factor for the development of dementia in Parkinson's disease. However, prior studies exploring the association between specific sleep-wake disturbances and neuropsychological functions have been limited.Methods: In this study, 101 patients with idiopathic Parkinson's disease were assessed neurologically, underwent neuropsychological testing, and completed self-report questionnaires covering nocturnal disturbance, excessive daytime sleepiness, and symptoms of rapid eye movement sleep behavior disorder.Results: Univariate correlations revealed differential patterns of neuropsychological performance in relation to nocturnal sleep disturbance, excessive daytime sleepiness, and rapid eye movement sleep behavior disorder. After controlling for potential confounders, excessive daytime sleepiness remained a significant predictor of slowed processing speed, and rapid eye movement sleep behavior disorder predicted working memory and verbal fluency performance. The relationships between nocturnal sleep disturbance and memory appeared to be mediated by education.Conclusions: These findings highlight the critical role that specific sleep-wake disturbances in Parkinson's disease might have on neuropsychological functioning, which may reflect common neural underpinnings. (C) 2011 Movement Disorder Society