Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.
Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.
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DOI：
10.1186/1753-6561-1-s1-s33
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Zhang K
中科院分区：
文献类型：
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作者：
Yoo YJ;Gao G;Zhang K
我们利用基因分析研讨会15中提供的北美类风湿性关节炎联合会(NARAC)的数据，对几个候选基因进行了类风湿关节炎(RA)的病例对照关联分析。我们使用所有相关病例和无关对照进行病例对照关联分析，并将结果与从每个家庭中随机选择一个病例和所有无关对照进行样本分析的结果进行比较。对于这两种分析，我们使用了基于单核苷酸多态(SNP)标记或单倍型的加权综合似然比检验，说明了家庭内样本之间的相关性。包括候选基因PTPN22中的R620W在内的几个SNP与RA状态有关，这证实了先前报道的结果。候选基因中的其他几个SNP，如CTLA4、HAVCR1和SUMO4，也有相当小的p值(<；0.05)，这表明它们与RA之间存在关联。我们的结果表明，从包括所有相关病例的分析中获得的p值一般小于从每个家庭中只随机选择一个病例的分析所获得的p值。这些结果与基于模拟数据的结果一起表明，在所有相关情况下都可以获得更高的功率。
We performed a case-control association analysis of rheumatoid arthritis (RA) for several candidate genes using the North American Rheumatoid Arthritis Consortium (NARAC) data provided in Genetic Analysis Workshop 15. We conducted the case-control association analysis using all related cases and unrelated controls and compared the results with those from the analysis of samples using only one randomly selected case from each family and all unrelated controls. For both analyses we used a weighted composite likelihood ratio test based on single-nucleotide polymorphism (SNP) markers or haplotypes accounting for the correlation among samples within a family. Several SNPs, including R620W in the candidate gene PTPN22, showed an association with RA status, which confirmed previously reported results. Several other SNPs in the candidate genes, such as CTLA4, HAVCR1, and SUMO4, also had rather small p-values (<0.05), suggesting the associations between them and RA. Our results showed that the p-values obtained from the analysis including all related cases were generally smaller than those obtained from the analysis including only one randomly selected case per family. These results, together with the results, based on simulated data, showed that higher power could be achieved using all related cases.