Contribution of glycaemic control, endogenous lipoproteins and cholesteryl ester transfer protein to accelerated cholesteryl ester transfer in IDDM
Contribution of glycaemic control, endogenous lipoproteins and cholesteryl ester transfer protein to accelerated cholesteryl ester transfer in IDDM
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DOI：
10.1111/j.1365-2362.1994.tb01112.x
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发表时间：
1994-09
影响因子：
5.5
通讯作者：
M. C. Ritter;J. Bagdade
中科院分区：
文献类型：
--
作者：
M. C. Ritter;J. Bagdade
摘要：在一项早期研究中，我们证明，在血脂正常的胰岛素依赖型糖尿病 (IDDM) 患者中，胆固醇酯 (CET) 的转移会加速，胆固醇酯 (CET) 的转移是在血浆孵育过程中加速的，而胆固醇酯 (CET) 的转移是加速的，而胆固醇酯 (CET) 的转移是加速的。采用相同的传质测定对分离的脂蛋白级分进行的重组实验表明，这种干扰是由 VLDL 功能障碍引起的，而不是由 CE 转移蛋白 (CETP) 活性的变化引起的。
Abstract In an earlier study we demonstrated that the transfer of cholesteryl ester (CET) estimated as the net mass of CE lost from HDL to the apoB‐containing lipoproteins (VLDL + LDL) during incubation of plasma is accelerated in normolipidaemic patients with insulin‐dependent diabetes mellitus (IDDM). Recombination experiments with isolated lipoprotein fractions employing this same mass transfer assay indicated that this disturbance resulted from dysfunction of VLDL and not from changes in the activity of CE transfer protein (CETP).