Impact and Influence of the Natural Vibrio-Squid Symbiosis in Understanding Bacterial-Animal Interactions.
Impact and Influence of the Natural Vibrio-Squid Symbiosis in Understanding Bacterial-Animal Interactions.
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DOI：
10.3389/fmicb.2016.01982
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发表时间：
2016
影响因子：
5.2
通讯作者：
Dunn AK
中科院分区：
文献类型：
--
作者：
Mandel MJ;Dunn AK
动物是细菌的殖民地，在许多情况下，合作伙伴已经共同进化，以执行互利的功能。过去十年的一个令人兴奋和持续的遗产是技术的扩展，使原位/体内自然协会的研究成为可能。因此，更多的共生关系正在被研究，更多的细节正在被揭示，重点是在本地环境中合作伙伴之间的相互作用。有了这个框架，我们回顾了最近的文献从弧菌fischeri-Euprymna的共生，并专注于关键的研究，有广泛的理解细菌-动物的相互作用的影响。这并不打算是一个全面的审查系统，而是专注于特定的研究，在促进理解的分子基础上，在宿主-微生物相互作用领域的有趣的观察，在移动模式的过程中表现出色。在这篇综述中，我们讨论了以下主题：调节菌株和物种特异性的过程;宿主形态发生的细菌信号;一氧化氮的多重作用;鞭毛运动和趋化性;以及努力了解未注释和注释不佳的基因。总体而言，这些研究表明，在一个易于处理的系统中，体内功能方法如何为微生物-宿主相互作用的一般原理提供了有价值的见解。
Animals are colonized by bacteria, and in many cases partners have co-evolved to perform mutually beneficial functions. An exciting and ongoing legacy of the past decade has been an expansion of technology to enable study of natural associations in situ/in vivo. As a result, more symbioses are being examined, and additional details are being revealed for well-studied systems with a focus on the interactions between partners in the native context. With this framing, we review recent literature from the Vibrio fischeri–Euprymna scolopes symbiosis and focus on key studies that have had an impact on understanding bacteria–animal interactions broadly. This is not intended to be a comprehensive review of the system, but rather to focus on particular studies that have excelled at moving from pattern to process in facilitating an understanding of the molecular basis to intriguing observations in the field of host–microbe interactions. In this review we discuss the following topics: processes regulating strain and species specificity; bacterial signaling to host morphogenesis; multiple roles for nitric oxide; flagellar motility and chemotaxis; and efforts to understand unannotated and poorly annotated genes. Overall these studies demonstrate how functional approaches in vivo in a tractable system have provided valuable insight into general principles of microbe–host interactions.