Assessing patient-reported peripheral neuropathy: the reliability and validity of the European Organization for Research and Treatment of Cancer QLQ-CIPN20 Questionnaire.
Assessing patient-reported peripheral neuropathy: the reliability and validity of the European Organization for Research and Treatment of Cancer QLQ-CIPN20 Questionnaire.
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DOI：
10.1007/s11136-013-0379-8
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发表时间：
2013-12
影响因子：
3.5
通讯作者：
Loprinzi, Charles L.
中科院分区：
文献类型：
--
作者：
Smith, Ellen M. Lavoie;Barton, Debra L.;Qin, Rui;Steen, Preston D.;Aaronson, Neil K.;Loprinzi, Charles L.
进行该临床分析以评价QLQ-CIPN 20用于量化患者报告的化疗诱导的周围神经病变（CIPN）时的可靠性、有效性和对转换时间的反应性。招募到四个合作组试验的参与者被合并为两组（n = 376，575）：接受神经毒性化疗的人与未接受神经毒性化疗的人。QLQ-CIPN 20内部一致性信度采用Cronbach α系数进行评估。工具的有效性进行了评估，使用因素分析，通过评估与其他CIPN和疼痛措施的相关性，并通过比较对比组之间的分数。科恩的d被用来评估对变化的反应。感觉、运动和自主神经量表的α系数分别为0.88、0.88和0.78。然而，自主神经量表和听力损失项目显示出较低的项目-项目相关性（r ≤ 0.30），因此被删除。QLQ-CIPN 20和简明疼痛量表疼痛严重程度项目之间存在中度相关性（r 0.30-0.57，p ≤ .0001）。QLQ-CIPN 20感觉和毒性分级量表评分之间的相关性较低（r = 0.20; p ≤ 0.01）。接受神经毒性化疗的个体与未接受神经毒性化疗的个体相比，平均评分更高（更差）（p ≤ 0.0001）。感觉和运动量表表现出中-高的反应变化（科恩的d = 0.82和0.48，分别）。因素分析表明，16项版本形成了不同的因素，下肢和上肢CIPN，描绘典型的远端到近端CIPN进展。结果支持QLQ-CIPN 20感觉和运动量表的信度和效度。更简约和临床相关的16项版本值得进一步考虑。
This clinimetric analysis was conducted to evaluate the reliability, validity, and responsiveness to changeover time of the QLQ-CIPN20 when used to quantify patient-reported chemotherapy-induced peripheral neuropathy (CIPN). Participants recruited to four cooperative group trials were pooled to create two groups (n = 376, 575): those who did versus did not receive neurotoxic chemotherapy. QLQ-CIPN20 internal consistency reliability was assessed using Cronbach's alpha coefficients. Instrument validity was assessed using factor analysis, by evaluating score correlations with other CIPN and pain measures, and by comparing scores between contrasting groups. Cohen's d was used to assess responsiveness to change. Alpha coefficients for the sensory, motor, and autonomic scales were 0.88, 0.88, and 0.78, respectively. However, autonomic scale and hearing loss items exhibited low item–item correlations (r ≤ 0.30) and thus were deleted. Moderate correlations were found between QLQ-CIPN20 and Brief Pain Inventory pain severity items (r 0.30–0.57, p ≤ .0001). Correlation between the QLQ-CIPN20 sensory and toxicity grading scale scores was low (r = .20; p ≤ .01). Mean scores were higher (worse) (p ≤ 0.0001) in individuals who did versus did not receive neurotoxic chemotherapy. The sensory and motor scales exhibited moderate-high responsiveness to change (Cohen's d = 0.82 and 0.48, respectively). Factor analysis indicated that the 16-item version formed distinct factors for lower and upper extremity CIPN, delineating typical distal to proximal CIPN progression. Results provide support for QLQ-CIPN20 sensory and motor scale reliability and validity. The more parsimonious and clinically relevant 16-item version merits further consideration.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
10.3
作者：
Basch, Ethan;Jia, Xiaoyu;Schrag, Deborah
通讯作者：
Schrag, Deborah
影响因子：
3.5
作者：
Boehmer, S;Luszczynska, A
通讯作者：
Luszczynska, A
影响因子：
2.2
作者：
Paice, Judith A
通讯作者：
Paice, Judith A
影响因子：
45.3
作者：
Loprinzi, Charles L.;Reeves, Brandi N.;Lachance, Daniel H.
通讯作者：
Lachance, Daniel H.