Flexible Sensorimotor Computations through Rapid Reconfiguration of Cortical Dynamics
Flexible Sensorimotor Computations through Rapid Reconfiguration of Cortical Dynamics
复制标题
DOI：
10.1016/j.neuron.2018.05.020
复制
发表时间：
2018-06-06
期刊：
影响因子：
16.2
通讯作者：
Jazayeri, Mehrdad
中科院分区：
文献类型：
--
作者：
Remington, Evan D.;Narain, Devika;Jazayeri, Mehrdad
支持灵活感觉运动计算的神经机制还没有得到很好的理解。在一个状态由神经元之间的相互作用决定的动态系统中，通过控制系统的输入和初始条件，可以快速地重新配置计算。为了研究大脑是否采用这种控制机制，我们记录了训练测量和产生两种感觉运动背景下的时间间隔的猴子的背内侧额叶皮层。在生产时期的神经轨迹的几何形状是一致的机制，其中所测量的间隔和感觉运动上下文施加控制皮质动力学通过调整系统的初始条件和输入，分别。这些调整反过来又设定了生产时期活动演变的速度，使动物能够灵活地生产不同的时间间隔。这些结果提供了证据，表明动力系统的语言可以用来将大脑活动与感觉运动计算联系起来。
Neural mechanisms that support flexible sensorimotor computations are not well understood. In a dynamical system whose state is determined by interactions among neurons, computations can be rapidly reconfigured by controlling the system's inputs and initial conditions. To investigate whether the brain employs such control mechanisms, we recorded from the dorsomedial frontal cortex of monkeys trained to measure and produce time intervals in two sensorimotor contexts. The geometry of neural trajectories during the production epoch was consistent with a mechanism wherein the measured interval and sensorimotor context exerted control over cortical dynamics by adjusting the system's initial condition and input, respectively. These adjustments, in turn, set the speed at which activity evolved in the production epoch, allowing the animal to flexibly produce different time intervals. These results provide evidence that the language of dynamical systems can be used to parsimoniously link brain activity to sensorimotor computations.