In vitro invasion assay using matrigel.
In vitro invasion assay using matrigel.
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DOI：
10.1385/1-59259-137-x:061
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Brooks, S A
中科院分区：
文献类型：
--
作者：
M, D;Brooks, S A
基底膜是由胶原、层粘连蛋白和蛋白聚糖等多种生物成分组成的特化细胞外基质。它们形成薄的连续片状结构，将上皮组织与相邻的结缔组织基质分开;因此，它们形成屏障，阻断细胞和其他大分子的通过。在组织发育、修复和炎症部位，基底膜变得可渗透，以允许免疫细胞到达该部位（1）。
Basement membranes are specialized extracellular matrices that are comprised of several biological components including collagens, laminins, and proteoglycans. They form thin continuous sheetlike structures that separate epithelial tissues from the adjacent connective tissue stroma; thus, they form barriers, which block the passage of cells and other macromolecules. The basement membranes become permeable during tissue development, repair, and at sites of inflammation, to allow immune cells to reach the site (1).