Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines
Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines
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DOI：
10.1016/j.tet.2013.07.067
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发表时间：
2013-09-30
期刊：
影响因子：
2.1
通讯作者：
Reynolds, Kevin A.
中科院分区：
文献类型：
--
作者：
Kancharla, Papireddy;Reynolds, Kevin A.
一系列新的3-烷基、4-烷基、3，4-二烷基和3-halo-4-alkyl-2，2‘-bipyrrole-5-carboxaldehydes的合成路线已经被开发出来。这些2，2‘-联吡咯-5-甲醛在合成生物活性天然和非天然产物方面提供了有趣的潜力，如B-环功能化前列腺素(PG)和TAMBJAMINS的合成所证明的那样。(C)爱思唯尔有限公司出版的2013年。
Facile, versatile, and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3,4-dialkyl-, and 3-halo-4-alkyl-2,2'-bipyrrole-5-carboxaldehydes have been developed. These 2,2'-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks for making bioactive natural and unnatural products, as demonstrated by the synthesis of B-ring functionalized prodiginines (PGs) and tambjamines. (C) 2013 Published by Elsevier Ltd.