Polyclonal antibody targeting SOX11 cannot differentiate mantle cell lymphoma from B-cell non-Hodgkin lymphomas.
Polyclonal antibody targeting SOX11 cannot differentiate mantle cell lymphoma from B-cell non-Hodgkin lymphomas.
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DOI：
10.1309/ajcpebouj7gvyvlg
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发表时间：
2013-12
影响因子：
3.5
通讯作者：
Li-Na Zhang;Xin Cao;Tingxun Lu;L. Fan;Li Wang;Ji Xu;Run Zhang;Zhi-jian Zou;Jia-zhu Wu;Jian-yong Li;W. Xu
中科院分区：
文献类型：
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作者：
Li-Na Zhang;Xin Cao;Tingxun Lu;L. Fan;Li Wang;Ji Xu;Run Zhang;Zhi-jian Zou;Jia-zhu Wu;Jian-yong Li;W. Xu
目的探讨SOX11是否为套细胞淋巴瘤(MCL)的诊断标记物。方法采用免疫组织化学方法检测349例B细胞性非霍奇金淋巴瘤(B-NHL)中Sox11的表达。结果58例MCL中54例(93.1%)SOX11表达阳性。在37例B淋巴母细胞淋巴瘤中8例(21.6%)，138例弥漫性大B细胞淋巴瘤中45例(32.6%)，34例滤泡性淋巴瘤中15例(44.1%)，26例Burkitt淋巴瘤中8例(30.8%)，20例慢性淋巴细胞白血病/小细胞淋巴瘤中2例(10.0%)，16例边缘带淋巴瘤中3例(18.8%)。结论尽管Sox11在B-NHL中的阳性表达显著高于其他B-NHL(P<；.001)，但针对Sox11的多克隆抗体不能区分MCL和B-NHL，因为Sox11的核染色在B-NHL中广泛阳性。
OBJECTIVES To determine whether SOX11 is a diagnostic marker of mantle cell lymphoma (MCL). METHODS We analyzed SOX11 expression in 349 B-cell non-Hodgkin lymphomas (B-NHLs) via immunohistochemistry. RESULTS Nuclear staining of SOX11 was observed in 54 (93.1%) of 58 MCLs. We noticed that SOX11 protein was also expressed on the nuclei in 8 (21.6%) of 37 B-lymphoblastic lymphomas, 45 (32.6%) of 138 diffuse large B-cell lymphomas, 15 (44.1%) of 34 follicular lymphomas, 8 (30.8%) of 26 Burkitt lymphomas, 2 (10.0%) of 20 chronic lymphocytic leukemia/small cell lymphomas, and 3 (18.8%) of 16 marginal zone lymphomas. CONCLUSIONS Although the positive rate of SOX11 expression in MCL was significantly higher than other B-NHLs (P < .001), polyclonal antibody targeting SOX11 is not able to identify MCL from B-NHLs because the nuclear staining of SOX11 was widely positive in B-NHLs.