Natural history of Helicobacter pylori infection in childhood:: 12-year follow-up cohort study in a biracial community
Natural history of Helicobacter pylori infection in childhood:: 12-year follow-up cohort study in a biracial community
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DOI：
10.1086/515105
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发表时间：
1999-02-01
影响因子：
11.8
通讯作者：
Berenson, GS
中科院分区：
文献类型：
--
作者：
Malaty, HM;Graham, DY;Berenson, GS
我们评估了一组212名儿童的幽门螺杆菌感染的获得和丧失模式，这些儿童来自一个具有同质社会经济阶层的双胞胎社区。这些儿童从儿童期到青年期随访了12年（1973-1974年至1985-1986年）。H.根据血清幽门螺杆菌IgG抗体的存在情况评估幽门螺杆菌的状况。幽门螺杆菌感染（40%的黑人对11%的白人; P = 0.0001）; 12年后，33%的血清学阳性。黑人的患病率仍然较高（P = .0001）。在随访期间，228名儿童感染;黑人的感染率是白人的四倍（P = 0.001）。在12年的时间里，50%的白人感染消失，而4%的黑人仍然感染或再次感染。H.在不同种族群体中，儿童期幽门螺杆菌感染受感染获得和丧失的影响。这一观察结果对于了解H.幽门感染
We assessed the pattern of acquisition and loss of Helicobacter pylori infection in a cohort of 212 children from a biracial community with a homogeneous socioeconomic class. The children were followed over 12 years (1973-1974 to 1985-1986) from childhood to young adulthood. H. pylori status was assessed by the presence of serum IgG antibodies to H, pylori, At ages 7-9, 198 of children had H. pylori infection (40% of blacks vs. 11% of whites; P = .0001); 12 years later, 33% were seropositive. The higher prevalence among blacks remained (P = .0001). During follow-up, 228 of children became infected; the rate of acquisition was fourfold greater among blacks than among whites (P = .001). Over the 12-year period, infection was lost in 50% of whites compared with 4% of blacks who either remained infected or became reinfected. H. pylori infection in childhood is affected by both acquisition and loss of infection in different ethnic groups. This observation is critical for understanding the epidemiology and transmission of H. pylori infection.