SEIZURE FOLLOWING BRIEF EXPOSURE TO THE INSECT REPELLENT N,N-DIETHYL-M-TOLUAMIDE
SEIZURE FOLLOWING BRIEF EXPOSURE TO THE INSECT REPELLENT N,N-DIETHYL-M-TOLUAMIDE
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DOI：
10.1016/s0196-0644(05)80896-0
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发表时间：
1992-03-01
影响因子：
6.2
通讯作者：
LEIKIN, JB
中科院分区：
文献类型：
--
作者：
LIPSCOMB, JW;KRAMER, JE;LEIKIN, JB
一名有轻度发育迟缓病史的5岁男孩在日间夏令营中局部使用驱虫剂Muskol（R）后发生了严重的运动性癫痫发作，随后使用了OFF（R）[均含有N，N-二乙基间甲苯酰胺（DEET）]。 患者在急诊室继续抽搐，并接受地西泮治疗。 实验室检查无异常，腰椎穿刺、计算机断层扫描和血培养也无异常。 进行了皮肤净化。 尿液中的DEET水平为0.003 μ g/mL。 尽管在涉及儿科患者局部暴露的既往病例报告中描述了使用DEET的癫痫发作和脑病综合征，但关于该病例的非典型方面包括该患者为男性（大多数其他病例报告涉及女性），与其他报告相比，暴露时间相对较短，患者发生癫痫发作，无既往报告中描述的前驱症状。 应考虑避免儿科患者使用高浓度避蚊胺制剂。
A 5-year-old boy with a history of mild developmental delay experienced a major motor seizure at day camp after topical application that morning of the insect repellent Muskol(R) and a later application of OFF(R) [both contain N,N-Diethyl-m-toluamide (DEET)]. The patient continued convulsing in the emergency department and was treated with diazepam. Laboratory tests were unremarkable, as were lumbar puncture, computed tomography scan, and blood cultures. Skin decontamination was performed. DEET levels in the urine were 0.003-mu-g/mL. Although seizures and encephalopathic syndrome have been described with DEET in previous case reports involving topical exposure of pediatric patients, atypical aspects with regard to this case include that this patient was a male (most other case reports involve females), exposure was relatively brief compared with other reports, and the patient developed seizures without a prodrome described in previous reports. Avoidance of high-concentration DEET formulations in pediatric patients should be considered.