Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali-Metal Amides under Air
Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali-Metal Amides under Air
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环境湿度在空气下加速乙烯基芳烃与碱金属酰胺的氢氨化反应
DOI：
10.1002/ange.202008512
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发表时间：
2020
影响因子：
--
通讯作者：
Mulks F
中科院分区：
文献类型：
--
作者：
Mulks F
报道了以生物可再生的2 -甲基四氢呋喃为溶剂进行苯乙烯直接碱金属介导的氢胺化反应。反驳了有机锂试剂与空气和水分不相容的传统观点，这里显示的是，相对于竞争的烯烃聚合产物，水分的存在是有利于目标苯乙胺形成的关键。该方法也与酰胺钠相容，后者在惰性气氛条件下作为高效催化剂表现出良好的前景。
A straightforward alkali‐metal‐mediated hydroamination of styrenes using biorenewable 2‐methyltetrahydrofuran as a solvent is reported. Refuting the conventional wisdom of the incompatibility of organolithium reagents with air and moisture, shown here is that the presence of moisture is key in favoring formation of the target phenethylamines over competing olefin polymerization products. The method is also compatible with sodium amides, with the latter showing excellent promise as highly efficient catalysts under inert atmosphere conditions.