The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions
The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions
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DOI：
10.1097/wad.0000000000000380
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发表时间：
2020-04-01
影响因子：
2.1
通讯作者：
Kukull, Walter
中科院分区：
文献类型：
--
作者：
Mock, Charles;Teylan, Merilee;Kukull, Walter
痴呆症研究领域正在迅速发展，特别是在我们对认知能力下降的神经病理变化多样性的理解方面。已知条件的定义和标准正在定期修订和完善，并正在进行有关痴呆状态相关的神经病理学特征的新发现。由国家阿尔茨海默氏症协调中心（NACC）维护的数据库为研究人员提供了一种强大，快速和统计学上有效的方法来评估新发现的神经病理学状况对合并症，人口统计学关联，认知状态，神经心理学测试，放射学发现和遗传学的影响。NACC的数据来自数十个优秀的美国阿尔茨海默病研究中心，这些研究中心纵向跟踪了数千名研究志愿者。许多研究参与者使用最先进的方法进行尸检。在这篇文章中，我们描述了NACC数据库，并给出了它在评估最近修订的神经病理学诊断，包括原发性年龄相关性tau蛋白病（PART），边缘系统占主导地位的年龄相关性TDP-43脑病（LATE），和阿尔茨海默病神经病理学变化的临床前阶段，根据国家老龄化研究所-阿尔茨海默病协会共识指南的使用的例子。鼓励痴呆症研究界利用这个现成的数据库，因为在这个快速发展的领域中，新的神经病理学变化被认识和定义。
The field of dementia research is rapidly evolving, especially with regards to our understanding of the diversity of neuropathologic changes that underlie cognitive decline. Definitions and criteria for known conditions are being periodically revised and refined, and new findings are being made about neuropathologic features associated with dementia status. The database maintained by the National Alzheimer's Coordinating Center (NACC) offer researchers a robust, rapid, and statistically well-powered method to evaluate the implications of newly identified neuropathologic conditions with regards to comorbidities, demographic associations, cognitive status, neuropsychologic tests, radiographic findings, and genetics. NACC data derive from dozens of excellent US Alzheimer disease research centers, which collectively follow thousands of research volunteers longitudinally. Many of the research participants are autopsied using state-of-the-art methods. In this article, we describe the NACC database and give examples of its use in evaluating recently revised neuropathologic diagnoses, including primary age-related tauopathy (PART), limbic predominant age-related TDP-43 encephalopathy (LATE), and the preclinical stage of Alzheimer disease neuropathologic change, based on the National Institute on Aging-Alzheimer's Association consensus guidelines. The dementia research community is encouraged to make use of this readily available database as new neuropathologic changes are recognized and defined in this rapidly evolving field.