HMGIC expressed in a uterine leiomyoma with a deletion of the long arm of chromosome 7 along with a 12q14-15 rearrangement but not in tumors showing del(7) as the sole cytogenetic abnormality
HMGIC expressed in a uterine leiomyoma with a deletion of the long arm of chromosome 7 along with a 12q14-15 rearrangement but not in tumors showing del(7) as the sole cytogenetic abnormality
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DOI：
10.1016/s0165-4608(96)00283-x
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发表时间：
1997-07-15
影响因子：
--
通讯作者：
Bullerdiek, J
中科院分区：
文献类型：
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作者：
Hennig, Y;Rogalla, P;Bullerdiek, J
对子宫平滑肌瘤的细胞遗传学研究表明，超过60%的这些肿瘤具有正常的核型，30%具有克隆性染色体畸变。最常见的变化是涉及12 q14 -15的畸变，并显示7号染色体长臂的重排。最近，我们能够证明，在各种间充质肿瘤显示12 q14 -15畸变的HMGIC基因重排，从而在肿瘤发生中发挥作用。在这里，我们报告的结果，HMGIC表达的RT-PCR研究5个子宫平滑肌瘤与不同的核型。对两个显示12 q14 -15畸变的原发性肿瘤进行了RT-PCR研究，其中一个具有额外的del（7），三个肿瘤具有del（7）作为唯一的畸变。12 q14 -15畸变为唯一改变的肿瘤和12 q14 -15重排加7号染色体长臂缺失的平滑肌瘤显示HMGIC表达。相反，在所有三个肿瘤中，del（7）是唯一的畸变，没有观察到HMGIC的表达。(C)Elsevier Science Inc.，1997.
Cytogenetic studies on uterine leiomyomas have shown that more than 60% of these tumors possess a normal karyotype and that 30% have clonal chromosomal aberrations. The most frequent changes are aberrations involving 12q14-15 and show rearrangements of the long arm of chromosome 7. Recently, we were able to demonstrate that in a variety of mesenchymal tumors showing 12q14-15 aberrations the HMGIC gene is rearranged thus playing a role in tumorigenesis. Here we report the results of HMGIC expression studies by RT-PCR of five uterine leiomyomas with different karyotypes. The RT-PCR studies were performed on two primary tumors showing a 12q14-15 aberration, one of which with an additional del(7) and three tumors with del(7) as the sole aberration. The tumor with the 12q14-15 aberration as the sole alteration and the leiomyoma with 12q14-15 rearrangement plus deletion of the long arm of chromosome 7 were shown to express HMGIC. In contrast, in all three tumors with the del(7) was the sole aberration no expression of HMGIC was noted. (C) Elsevier Science Inc., 1997.