Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells
Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells
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细胞质甲胎蛋白作为 RA-RAR 信号传导的共阻遏物，促进人肝癌 Bel 7402 细胞的生长。
DOI：
10.1016/j.canlet.2009.05.014
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发表时间：
2009-11-28
期刊：
影响因子：
9.7
通讯作者：
Li, Gang
中科院分区：
文献类型：
--
作者：
Li, Mengsen;Li, Hui;Li, Gang
研究甲胎蛋白在人肝癌Bel 7402细胞维甲酸-RAR信号通路中的作用。结果表明，AFP和RAR-β在细胞质中共定位并相互作用。AFP可能通过与ATRA竞争性结合RAR-β而抑制RAR-β的核内转位，该作用可被AFP-siRNA逆转。我们的数据表明，Bel 7402细胞对全反式维甲酸的耐药性至少部分归因于其高水平的细胞质AFP。因此，通过抵消AFP的作用，有可能增加肿瘤细胞对全反式维甲酸的敏感性。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-beta were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-beta into the nucleus via competitive binding to RAR-beta with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA. (C) 2009 Elsevier Ireland Ltd. All rights reserved.