The PBC domain contains a MEINOX domain: Coevolution of hox and TALE homeobox genes?
The PBC domain contains a MEINOX domain: Coevolution of hox and TALE homeobox genes?
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DOI：
10.1007/s004270050161
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发表时间：
1998-04-01
影响因子：
2.4
通讯作者：
Burglin, TR
中科院分区：
文献类型：
--
作者：
Burglin, TR
最近对TALE超类同源盒基因的调查揭示了在植物KNOX基因和动物MEIS基因之间保守的同源结构域上游的新结构域。与此同时，另一篇论文将果蝇基因homothorax（hth）鉴定为脊椎动物MEIS基因的同源物，这促使人们重新检查MEIS，KNOX（统称为MEINOX）和PBC结构域的序列。在PBC结构域内发现了完整的MEINOX结构域的相似性。这表明PBC类基因也来源于古老的MEINOX基因。最近，已经表明MEIS基因可以与Abd-B基因相互作用，而先前的结果已经表明PBC基因与前Hox基因相互作用。这导致了一种假设，即祖先MEINOX基因复制成PBC和MEIS基因发生在前两个Hox簇基因（前一个和后一个）出现的时间点，随后这些基因类共同进化。
A recent survey of TALE superclass homeobox genes revealed a new domain upstream of the homeodomain that is conserved between the plant KNOX genes and the animal MEIS genes. At the same time, another paper identified the Drosophila gene homothorax (hth) as a homologue of the vertebrate MEIS genes, which prompted a reexamination of the sequences of the MEIS, KNOX (collectively named MEINOX) and PBC domains. Similarity of the complete MEINOX domain was found within the PBC domain. This suggests that the PBC class genes were also derived from the ancient MEINOX genes. Recently, it has been shown that the MEIS genes can interact with the Abd-B genes, whilst previous results have shown that the PBC genes interact with anterior Hox genes. This leads to the hypothesis that the duplication of an ancestral MEINOX gene into the PBC and MEIS genes happened at a point in time when the first two Hox cluster genes, an anterior one and a posterior one, emerged, and that subsequently these gene classes coevolved.