Models for the self-assembly of basement membrane.
Models for the self-assembly of basement membrane.
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DOI：
10.1177/34.1.3510247
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发表时间：
1986-01
期刊：
影响因子：
--
通讯作者：
P. Yurchenco;E. Tsilibary;A. Charonis;H. Furthmayr
中科院分区：
文献类型：
--
作者：
P. Yurchenco;E. Tsilibary;A. Charonis;H. Furthmayr
基底膜含有许多固有的大分子组分，这些组分对于这些结构是独特的，并且它们协同组装成特定的杂聚物基质。IV型胶原蛋白三螺旋单体在其氨基末端、羧基末端和侧结构域结合在一起以形成网格状阵列。层粘连蛋白在两步过程中，在其末端球状结构域与自身结合以形成聚合物，并且还在胶原蛋白链上的两个不同位点沿着结合胶原蛋白。已发现硫酸乙酰肝素蛋白聚糖结合胶原蛋白和层粘连蛋白两者，表明可逆交联功能。基于自相关研究的数据，我们有可能开始考虑这些普遍存在的矩阵的组装和结构模型。
Basement membranes contain a number of intrinsic macromolecular components which are unique to these structures and which cooperatively assemble into specific heteropolymeric matrices. Type IV collagen triple helical monomers bind together at their amino-terminal, carboxy-terminal, and lateral domains to form a lattice-like array. Laminin, in a two-step process, binds to itself at its terminal globular domains to form polymers and also binds collagen at two distinct sites along the collagen chain. Heparan sulfate proteoglycan has been found to bind both collagen and laminin, suggesting a reversible crosslinking function. On the basis of the data derived from self-association studies, it is possible to begin considering models for the assembly and structure of these ubiquitous matrices.