Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells
Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells
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DOI：
10.1016/j.virusres.2007.03.006
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发表时间：
2007-06-01
期刊：
影响因子：
5
通讯作者：
Park, Sun
中科院分区：
文献类型：
--
作者：
Hong, Seung-Ho;Cho, Okki;Park, Sun
干扰素-lambda （IFN-lambda）对几种病毒的抗病毒活性已被报道，但尚未研究人类IFN-lambda是否能影响乙型肝炎病毒（HBV）在人肝细胞源性细胞中的复制。我们发现，在高浓度IFN-lambda治疗后，HBV在人肝癌细胞系中的复制减少了约30%。此外，我们发现HBV在另一种人肝癌细胞系中的复制不受IFN-lambda的抑制。然而，这些细胞系显示异二聚体ifn -受体和IFN-lambda诱导的抗病毒蛋白的转录水平相似。我们的研究结果表明，IFN-lambda对HBV的抗病毒活性可能在人细胞中有限。(C) 2007 Elsevier B.V.版权所有
The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells. (C) 2007 Elsevier B.V. All rights reserved.