Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
复制标题
DOI：
10.1016/j.neuint.2003.11.006
复制
发表时间：
2004-09-01
影响因子：
4.2
通讯作者：
Abbott, NJ
中科院分区：
文献类型：
--
作者：
Abbott, NJ
本文综述了脑间质液（ISF）通过优先途径流经大脑的证据，以及其与脑脊液（CSF）的关系。超过100年的研究提出了几个有争议的问题，但并不是所有的问题都得到了解决。最近的研究有效地结合了组织学和数学方法。综上所述，证据表明，大鼠脑内沿沿着优先通路（尤其是血管周围空间和轴突束）的ISF总体流速为0.1-0.3穆尔min（-1）g（-1）。这种液体的主要来源可能是脑毛细血管内皮，其具有必要的离子转运蛋白、通道和水渗透性，以低速率产生液体，c1/100的CSF分泌速率/平方厘米穿过脉络丛上皮。也有证据表明，部分CSF可从蛛网膜下腔循环进入脑腹侧表面的动脉血管周围空间，并加入循环的ISF，通过静脉血管周围空间和轴突束回流至CSF隔室，并通过蛛网膜颗粒和沿着颅神经流出至颈部神经。ISF的整体流动对非突触细胞有影响：细胞通讯（体积传输）;药物递送、分布和清除;脑离子稳态及其在脑水肿中的干扰;脑的免疫功能; β-淀粉样蛋白沉积物的清除;以及细胞（恶性细胞、干细胞）的迁移。(C)2003 Elsevier Ltd.保留所有权利。
This review surveys evidence for the flow of brain interstitial fluid (ISF) via preferential pathways through the brain, and its relation to cerebrospinal fluid (CSF). Studies over >100 years have raised several controversial points, not all of them resolved. Recent studies have usefully combined a histological and a mathematical approach. Taken together the evidence indicates an ISF bulk flow rate of 0.1-0.3 mul min(-1) g(-1) in rat brain along preferential pathways especially perivascular spaces and axon tracts. The main source of this fluid is likely to be the brain capillary endothelium, which has the necessary ion transporters, channels and water permeability to generate fluid at a low rate, c1/100th of the rate per square centimeter of CSF secretion across choroid plexus epithelium. There is also evidence that a proportion of CSF may recycle from the subarachnoid space into arterial perivascular spaces on the ventral surface of the brain, and join the circulating ISF, draining back via venous perivascular spaces and axon tracts into CSF compartments, and out both through arachnoid granulations and along cranial nerves to the lymphatics of the neck. The bulk flow of ISF has implications for non-synaptic cell:cell communication (volume transmission); for drug delivery, distribution, and clearance; for brain ionic homeostasis and its disturbance in brain edema; for the immune function of the brain; for the clearance of beta-amyloid deposits; and for the migration of cells (malignant cells, stem cells). (C) 2003 Elsevier Ltd. All rights reserved.