Asymmetric dimethylarginine is an independent risk factor for coronary heart disease:: Results from the multicenter coronary artery risk determination investigating the influence of ADMA concentration (CARDIAC) study
Asymmetric dimethylarginine is an independent risk factor for coronary heart disease:: Results from the multicenter coronary artery risk determination investigating the influence of ADMA concentration (CARDIAC) study
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DOI：
10.1016/j.ahj.2006.06.005
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发表时间：
2006-09-01
影响因子：
4.8
通讯作者：
Boeger, Rainer H.
中科院分区：
文献类型：
--
作者：
Schulze, Friedrich;Lenzen, Henrike;Boeger, Rainer H.
背景：不对称二甲基精氨酸（ADMA）血浆水平在与内皮功能障碍相关的疾病中升高，如高血压、高脂血症、糖尿病等。研究表明，ADMA可预测冠心病患者的心血管死亡率。然而，问题是否ADMA是一个独立的危险因素，冠心病仍然悬而未决。方法的心脏研究是一个多中心的病例对照研究，旨在检测ADMA血浆水平的差异与CHID患者和控制从一般人群。结果发现病例组血浆ADMA水平高于对照组（0.70 μ mol/L [0.59-0.87 μ mol/L] vs 0.60 μ mol/L [0.54-0.69 μ mol/L]，P <0.001）。为了评估ADMA对冠心病的预测能力，我们计算了包括实验室参数和传统危险因素的2个多变量logistic回归模型。在包括实验室特征的多变量模型中，ADMA的比值比为2.59（1.61-4.17; P < .001）;包括其他危险因素的多变量模型的比值比为6.04第三个三分位数（> 0.72 μ mol/L）与第一个三分位数（< 0.58 μ mol/L）比较（2.56-14.25; P <0.001）。
Background Asymmetric dimethylarginine (ADMA) plasma levels have been shown to be elevated in diseases related to endothelial dysfunction such as hypertension, hyperlipidemia, diabetes mellitus, and others. It has been shown that ADMA predicts cardiovascular mortality in patients who have coronary heart disease (CHD). However, the question whether ADMA is an independent risk factor for CHD still remains unresolved.Methods The CARDIAC study is a multicenter case-control study, designed to detect differences in ADMA plasma levels between patients with CHID and controls from the general population. We included in our analysis 13 1 cases and 13 1 controls, matched for age, sex, and body mass index.Results We found that cases had higher ADMA plasma levels than controls (0.70 mu mol/L [0.59-0.87 mu mol/L] vs 0.60 mu mol/L [0.54-0.69 mu mol/L], P < .001). To evaluate the predictive power of ADMA regarding CHD, we calculated 2 multivariate logistic regression models including laboratory parameters and traditional risk factors. The odds ratio for ADMA in the multivariate model including the laboratory characteristics was 2.59 (1.61-4.17; P < .001); the odds ratio for the multivariate model including other risk factors was 6.04 (2.56-14.25; P < .001) for the third tertile (> 0.72 mu mol/L) versus the first (< 0.58 mu mol/L).Conclusions We conclude from the results of our study that ADMA is an independent risk factor for CHD.