The clinical role of IL-23p19 in patients with rheumatoid arthritis
The clinical role of IL-23p19 in patients with rheumatoid arthritis
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DOI：
10.1080/03009740701286813
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Kim, H-Y
中科院分区：
文献类型：
--
作者：
Kim, H-R;Kim, H-S;Kim, H-Y
目的：为探讨类风湿关节炎（RA）患者关节液和循环中白细胞介素（IL）-23 p19（IL-23 p19）过度表达的临床意义以及IL-23 p19与其他细胞因子如IL- 17、肿瘤坏死因子（TNF）α和IL- 1 β的相关性。测量关节压痛/肿胀计数、100 mm视觉模拟评分（VAS）、红细胞沉降率（ESR）、C反应蛋白（CRP）、类风湿因子（RF）和抗环瓜氨酸肽抗体（抗CCP Ab）。骨侵蚀通过X线确定。结果：IL-23 p19与IL-17、TNF α和IL-1 β在SF和血清中的浓度呈正相关，与血清中TNF α和IL-1 β的浓度呈正相关。SF IL-23 p19浓度在有骨质侵蚀的患者中高于那些没有骨质侵蚀的患者。结论：SF中IL-23 p19表达上调可能通过与IL-17、TNF α、IL-1 β等细胞因子相互作用参与RA关节的破坏。
Objective: To determine the clinical implications of the over-expression of synovial and circulating interleukin (IL)-23p19 and the correlation between IL-23p19 and other cytokines such as IL- 17, tumour necrosis factor (TNF)alpha, and IL- 1 beta in rheumatoid arthritis (RA).Methods: Synovial fluid (SF) and sera of 22 patients with RA were obtained during knee arthrocentesis and stored at 220 C. Tender/ swollen joint counts, 100-mm visual analogue scale ( VAS), erythrocyte sedimentation rate (ESR), C- reactive protein ( CRP), rheumatoid factor (RF), and antibodies to cyclic citrullinated peptide ( anti- CCP Ab) were measured. Bony erosions were determined by X-rays. Serum and SF IL-23p19, IL-17, TNF alpha, and IL-1 beta concentrations were measured by sandwich enzyme-linked immunosorbent assay ( ELISA).Results: The concentration of IL-23p19 correlated with the concentration of IL-17 in SF and sera, and with the concentrations of TNF alpha and IL-1 beta in sera. SF IL-23p19 concentration was higher in patients who had bony erosions than those who had not. However, there was no correlation between IL-23p19 concentrations and other clinical parameters of RA.Conclusion: Upregulated IL-23p19 in SF might be involved in joint destruction in RA through interplay with other cytokines such as IL-17, TNF alpha, and IL-1 beta.