The significance of the pattern of serum CA125 level ascent to above the normal range in epithelial ovarian, primary peritoneal and tubal carcinoma patients
The significance of the pattern of serum CA125 level ascent to above the normal range in epithelial ovarian, primary peritoneal and tubal carcinoma patients
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DOI：
10.1016/j.ygyno.2012.12.024
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发表时间：
2013-04-01
影响因子：
4.7
通讯作者：
Menczer, Joseph
中科院分区：
文献类型：
--
作者：
Levy, Tally;Weiser, Roi;Menczer, Joseph
目标。在卵巢癌、腹膜癌和输卵管癌患者的随访中，CA125标记物的升高高于正常范围，且在最初治疗后临床反应完全，则意味着复发。我们评估复发时CA125升高到高于正常范围的模式是否与预后相关。摘录1998-2007年间所有复发性卵巢癌、原发性腹膜癌和输卵管癌患者的病历。纳入的患者符合以下标准：CA125水平在诊断时和复发时=35U/mL，他们接受了完全的初步治疗，完全的临床和放射学反应，按计划进行随访，并在随访期至少有两个CA125结果在正常范围内。比较CA125升高到正常范围以上的两种模式：渐进性升高和陡然升高。符合纳入标准的52例复发性疾病患者入选。渐进型患者的中位无进展和总生存期明显长于突变型患者(22.96vs14.07vs14.07；P=0.0014；44.37vs.中位数尚未达到)。多因素分析显示，CA125升高模式是无进展和总生存期的独立预测因素。我们的数据似乎表明，在复发时，临床完全缓解患者血清CA125水平升高到高于正常范围的模式对预后有价值。(C)2013 Elsevier Inc.保留所有权利。
Objective. A rise of the CA125 marker above the normal range during follow-up of ovarian, primary peritoneal and tubal carcinoma patients with a complete clinical response after initial treatment signifies recurrence. We assessed whether the pattern of CA125 ascent to above the normal range at recurrence is associated with outcome.Methods. The records of all recurrent ovarian primary peritoneal and tubal carcinoma patients diagnosed during 1998-2007 were abstracted. Included were patients who fulfilled the following criteria: CA125 levels were >= 35 U/mL at diagnosis and at recurrence, they had full primary treatment with a complete clinical and radiographic response, were followed-up according to schedule, and had at least two CA125 results within the normal range during follow-up. Two patterns of CA125 ascent to above the normal range were compared: a gradual rise and an abrupt rise.Results. 52 patients with recurrent disease who met the inclusion criteria were identified. The median progression free and overall survival were significantly longer in patients with a gradual than in those with an abrupt rise (22.96 vs 14.07; P=0.0014; and 44.37 vs. median not yet reach, respectively). Multivariate analysis showed that the pattern of CA125 ascent is an independent predictor of progression free and overall survival.Conclusions. Our data seem to indicate that at recurrence the pattern of ascent of serum CA125 levels to above the normal range in patients in complete clinical remission is of prognostic value. (C) 2013 Elsevier Inc. All rights reserved.