ALZHEIMERS PRESENILE-DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWNS-SYNDROME IN MIDDLE-AGE FORM AN AGE-RELATED CONTINUUM OF PATHOLOGICAL-CHANGES
ALZHEIMERS PRESENILE-DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWNS-SYNDROME IN MIDDLE-AGE FORM AN AGE-RELATED CONTINUUM OF PATHOLOGICAL-CHANGES
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DOI：
10.1111/j.1365-2990.1984.tb00351.x
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发表时间：
1984-01-01
影响因子：
5
通讯作者：
MARCYNIUK, B
中科院分区：
文献类型：
--
作者：
MANN, DMA;YATES, PO;MARCYNIUK, B
研究人员在 22 名年龄在 48-92 岁之间的阿尔茨海默病患者和 6 名年龄 > 50 岁的唐氏综合症患者中测量到了 Meynert 基底核和蓝斑神经细胞的损失以及存活细胞核仁体积的减少，这些患者的大脑皮层内也显示出广泛的老年斑和神经原纤维缠结的形成。与年龄匹配的对照组相比，这些变化的严重程度在年轻的阿尔茨海默病患者中最为严重，但这种变化随着年龄的增长而下降，到 80 岁时，阿尔茨海默病的变化水平接近老年时的水平。阿尔茨海默病患者的这些病理变化的程度仅存在轻微差异。阿尔茨海默病的早老性痴呆、阿尔茨海默型的老年性痴呆和中年唐氏综合症都形成了与年龄相关的病理变化连续体。
A loss of nerve cells from the nucleus basalis of Meynert and the locus caeruleus together with a reduction in nucleolar volume in surviving cells was measured in 22 patients with Alzheimer''s disease who ranged in age from 48-92 yr, and in 6 patients > 50 yr of age with Down''s syndrome who also showed extensive formation of senile plaques and neurofibrillary tangles within their cerebral cortex. When compared with age matched controls the severity of these changes was greatest in the younger paients with Alzheimer''s disease, but this fell with age such that by 80 yr the level of change in Alzheimer''s disease approached that in old age alone. There were only slight differences in the extent of these pathological changes in those patients with Alzheimer''s disease. The presenile dementia of Alzheimer''s disease, the senile dementia of Alzheimer type and Down''s syndrome in middle age all form an age-related continuum of pathological change.