Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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DOI：
10.1053/j.gastro.2016.12.048
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发表时间：
2017-05-01
期刊：
影响因子：
29.4
通讯作者：
Nieuwdorp, Max
中科院分区：
文献类型：
--
作者：
Bouter, Kristien E.;van Raalte, Daniel H.;Nieuwdorp, Max
在过去的十年里，肠道微生物区系在各种人类疾病的病因学中的潜在作用引起了人们的广泛关注。因此，肠道微生物区系在肥胖和肥胖相关代谢功能障碍等疾病的发展中起着重要的作用。在动物模型上的实验已经证明了肠道微生物区系在肥胖和胰岛素抵抗的病因中所起的因果作用。然而，除了少数例外，这种因果关系对人类来说是缺乏的，大多数出版物只报道了肠道微生物组成与肥胖和2型糖尿病等代谢紊乱之间的联系。因此，细菌和这些代谢紊乱之间的相互关系仍然是一个有争议的问题。本综述的主要目的是批判性地评估肠道微生物组成在肥胖和肥胖相关代谢功能障碍(包括2型糖尿病)的病因、预防和治疗中的驱动作用。
The potential role of intestinal microbiota in the etiology of various human diseases has attracted massive attention in the last decade. As such, the intestinal microbiota has been advanced as an important contributor in the development of obesity and obesity-related metabolic dysfunctions, amongst others. Experiments in animal models have produced evidence for a causal role of intestinal microbiota in the etiology of obesity and insulin resistance. However, with a few exceptions, such causal relation is lacking for humans and most publications merely report associations between intestinal microbial composition and metabolic disorders such as obesity and type 2 diabetes. Thus, the reciprocal relationship between the bacteria and these metabolic disorders remains a matter of debate. The main objective of this review is to critically assess the driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes.