Induction and regulation of CD8+cytolytic T cells in human tuberculosis and HIV infection
Induction and regulation of CD8+cytolytic T cells in human tuberculosis and HIV infection
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DOI：
10.1016/j.bbrc.2010.02.141
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发表时间：
2010-05-21
影响因子：
3.1
通讯作者：
Andersson, Jan
中科院分区：
文献类型：
--
作者：
Brighenti, Susanna;Andersson, Jan
结核病和艾滋病毒仍然是传染病中的世界头号杀手，主要影响许多发展中国家的穷人。尽管人类感染结核病和艾滋病毒的免疫发病机制存在差异，但临床研究和相关动物模型的实验证据可用于反映艾滋病毒感染者活动性结核病风险增加的细胞机制。本文就溶细胞性T细胞的分子特征及其调控机制，以及溶细胞性T细胞应答缺陷如何在结核病和HIV感染以及结核病/HIV共感染的发病机制中发挥作用进行综述。(C)2010年爱思唯尔公司All rights reserved.
Tuberculosis and HIV continue to be the world-leading killers among infectious diseases, primarily affecting poor people in many developing countries. Despite differences in the immunopathogenesis of human infection with tuberculosis and HIV, experimental evidence from clinical studies and relevant animal models can be used to reflect on the cellular mechanisms responsible for an increased risk of active tuberculosis among HIV-infected individuals. In this review, we will discuss the molecular features and regulation of cytolytic T cells and how deficient cytolytic T cell responses contribute to the pathogenesis of TB and HIV infection as well as TB/HIV co-infection. (C) 2010 Elsevier Inc. All rights reserved.