Fabrication and assembly of porous micropatterned scaffolds for modular tissue engineering
Fabrication and assembly of porous micropatterned scaffolds for modular tissue engineering
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用于模块化组织工程的多孔微图案支架的制造和组装
DOI：
10.1016/j.matlet.2018.06.045
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发表时间：
2018
影响因子：
3
通讯作者：
Hongsong Fan
中科院分区：
文献类型：
--
作者：
Wenqian Xiao;Haibo Xi;Jiale Li;Dan Wei;Bo Li;Xiaoling Liao;Hongsong Fan
在本文中，我们提出了一种有效且简单的方法来制造用于模块化组织工程的具有高图案保真度和开放多孔结构的新型微支架。我们表征了微结构，探讨了形成机制，并评估了细胞在微支架中的生长。此外，微支架块组装的表面张力驱动的组装，以构建具有可控的细胞分布和细胞相互作用的工程组织。这种微支架可以作为构建块来创建3D仿生工程组织。
In this paper, we present an efficient and simple approach to fabricate a novel microscaffold with high pattern fidelity and an open porous structure for modular tissue engineering. We characterized the microstructure, explored the formation mechanism, and evaluated the growth of cells in the microscaffold. Moreover, microscaffold blocks were assembled by surface tension-driven assembly to construct engineered tissue with controlled cell distribution and cell interactions. This microscaffold could be potentially applied as a building block to create 3D biomimetic engineered tissue.