First characterization of fluoroquinolone resistance in Streptococcus suis
First characterization of fluoroquinolone resistance in Streptococcus suis
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DOI：
10.1128/aac.00972-06
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发表时间：
2007-02-01
影响因子：
4.9
通讯作者：
Gonzalez-Zorn, Bruno
中科院分区：
文献类型：
--
作者：
Antonio Escudero, Jose;San Millan, Alvaro;Gonzalez-Zorn, Bruno
我们对氟喹诺酮敏感和耐药猪链球菌临床分离株ParC和GyrA的喹诺酮耐药决定区（QRDR）基因进行了鉴定和测序。耐药是ParC和GyrA的qrdr单点突变的结果，而不是由于耐药菌株的克隆传播或与其他细菌的水平基因转移。
We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria.