Low-dose misoprostol for the prevention of low-dose aspirin-induced gastroduodenal injury
Low-dose misoprostol for the prevention of low-dose aspirin-induced gastroduodenal injury
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DOI：
10.1046/j.1365-2036.2000.00739.x
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发表时间：
2000-05-01
影响因子：
7.6
通讯作者：
Hawkey, CJ
中科院分区：
文献类型：
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作者：
Donnelly, MT;Goddard, AF;Hawkey, CJ
前言：非甾体抗炎药(NSAIDs)对胃粘膜的损害与米索前列醇的预防作用均呈剂量依赖性。目的：探讨小剂量米索前列醇是否足以预防小剂量阿司匹林所致的胃粘膜损伤。方法：对32名可评价的志愿者进行双盲、安慰剂对照、平行对照的胃镜检查。主要观察指标是超过28天的胃黏膜糜烂性损伤(溃疡和浅表糜烂)。结果：大多数受试者每天服用300 mg阿司匹林后出现糜烂。每天服用100毫克米索前列醇可显著减少这种情况。(优势比0.18，95%可信区间：0.07~0.48)。服用米索前列醇的受试者未发生药物相关及胃肠道不良反应。结论：每天服用100 mg米索前列醇可预防小剂量阿司匹林所致的胃粘膜损伤，且不会引起明显的不良反应。
Introduction: The harmful effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the gastric mucosa and the prophylactic effects of misoprostol are both dose-dependent.Aim: To investigate whether a low-dose of misoprostol is sufficient to prevent gastric mucosal injury caused by low-dose aspirin.Methods: We conducted a double-blind placebo controlled parallel group endoscopic study in 32 evaluable volunteers. The main outcome measure was erosive injury (ulcers and superficial erosions) in the gastric mucosa over 28 days.Results: Most subjects developed erosions on aspirin 300 mg daily. This was significantly reduced by misoprostol 100 mu g daily. (Odds ratio 0.18, 95% CI: 0.07-0.48). There were no drug-related or gastrointestinal adverse events in subjects receiving misoprostol.Conclusion: Misoprostol 100 mu g daily can prevent low-dose aspirin induced gastric mucosal injury without causing identifiable adverse effects.